TY - JOUR
T1 - Laboratory measurement of adaptive behavior change in humans with a history of substance dependence
AU - Lane, Scott D.
AU - Cherek, Don R.
AU - Dougherty, Donald M.
AU - Moeller, F. Gerard
N1 - Funding Information:
This research was supported by a grant (DA 10592) and a fellowship (DA 05774) from the National Institute on Drug Abuse. We would like to thank Howard Rhoades for expert statistical analyses, and Sheila White, David Huang, and Angela Hamilton, for their assistance conducting these experiments.
PY - 1998/8/1
Y1 - 1998/8/1
N2 - Individuals vary in their ability to adapt to changes in environmental conditions. In the present study, two laboratory experiments investigated components of adaptation in subjects with and without a history of substance dependence. In each of two experiments, the subjects were exposed to conditions that required changing response patterns between experimental days. On day 1, subjects earned monetary rewards under conditions that produced high rate responding, but on day 2 were required to wait 10 s between each response. Collectively, the two experiments demonstrated that the subjects meeting criteria for past substance dependence, and having extensive histories of substance use (> 10 years), adjusted poorly to the transition. In both studies, these subjects tended to persevere on the previously established high-rate response pattern. These data suggest a deficiency in adaptive behavior change, particularly when that change requires an abrupt slowing of response rates following a brief history of high-rate responding.
AB - Individuals vary in their ability to adapt to changes in environmental conditions. In the present study, two laboratory experiments investigated components of adaptation in subjects with and without a history of substance dependence. In each of two experiments, the subjects were exposed to conditions that required changing response patterns between experimental days. On day 1, subjects earned monetary rewards under conditions that produced high rate responding, but on day 2 were required to wait 10 s between each response. Collectively, the two experiments demonstrated that the subjects meeting criteria for past substance dependence, and having extensive histories of substance use (> 10 years), adjusted poorly to the transition. In both studies, these subjects tended to persevere on the previously established high-rate response pattern. These data suggest a deficiency in adaptive behavior change, particularly when that change requires an abrupt slowing of response rates following a brief history of high-rate responding.
KW - Behavioral adaptation
KW - Changing contingencies
KW - Drug use history
KW - IRT
KW - Laboratory task
UR - http://www.scopus.com/inward/record.url?scp=0032143671&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032143671&partnerID=8YFLogxK
U2 - 10.1016/S0376-8716(98)00045-3
DO - 10.1016/S0376-8716(98)00045-3
M3 - Article
C2 - 9787997
AN - SCOPUS:0032143671
VL - 51
SP - 239
EP - 252
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
IS - 3
ER -