La Crosse virus G1 glycoprotein undergoes a conformational change at the pH of fusion

Francisco Gonzalez-Scarano

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

La Crosse virus, a member of the family Bunyaviridae, can mediate cell-to-cell fusion after mild acidification. Either of its two envelope glycoproteins could potentially be responsible for this function. The large glycoprotein (Gl) undergoes a conformational change at the pH of activation of the fusion function, resulting in both an alteration in the cleavage pattern produced by amino-acid-specific proteases, and in a change in its antigenicity, as defined by altered binding of monoclonal antibodies.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalVirology
Volume140
Issue number2
DOIs
StatePublished - Jan 30 1985

ASJC Scopus subject areas

  • Virology

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