L3T4+ T cells regulate Abelson virus-induced lymphomagenesis

A. J. Infante, S. Boulware, M. Cagle

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

To evaluate the role of T cells in regulation of lymphomagenesis, experiments were performed using Abelson murine leukemia virus (AMuLV). In vitro transformation of bone marrow target cells by this B lymphotropic retrovirus was inhibited by peripheral lymph node cells from naive mice. The inhibitory activity depended on Thy-1+ L3T4+ cells but did not require Lyt-2+ cells. In vivo depletion of L3T4+ T cells with mAb (GK1.5) altered the course of AMuLV-induced lymphoma. L3T4 depletion of naturally resistant C57BL/6 mice resulted in dramatic susceptibility to lymphoma induction. Lymphoma cells from anti-L3T4-treated C57BL/6 mice infected with AMuLV displayed the B lineage transformation marker P160(6C3). These studies reveal an important immunologic component of Abelson disease resistance involving L3T4+ T cells.

Original languageEnglish (US)
Pages (from-to)2462-2465
Number of pages4
JournalJournal of Immunology
Volume140
Issue number7
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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