L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors

Jianguo Fang, Haitao Ji, Graham R. Lawton, Fengtian Xue, Linda J. Roman, Richard B. Silverman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A common dichotomy exists in inhibitor design: should the compounds be designed to block the enzymes of animals in the preclinical studies or to inhibit the human enzyme? We report that a single mutation of Leu-337 in rat neuronal nitric oxide synthase (nNOS) to His makes the enzyme resemble human nNOS more than rat nNOS. We expect that the approach used in this study can unite the dichotomy and speed up the process of inhibitor design and development.

Original languageEnglish (US)
Pages (from-to)4533-4537
Number of pages5
JournalJournal of Medicinal Chemistry
Volume52
Issue number14
DOIs
StatePublished - Jul 23 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Fingerprint Dive into the research topics of 'L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors'. Together they form a unique fingerprint.

  • Cite this