l-5-Hydroxytryptophan-induced flat body posture in the rat: antagonism by ritanserin and potentiation after 5,7-dihydroxytryptamine

Francis C. Colpaert, Wouter Koek, Andries Lategan

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

l-5-Hydroxytryptophan (l-5-HTP)-induced flat body posture (FBP) was antagonized by ritanserin in doses that were lower than those needed to antagonize head-twitches (HTW) and forepaw treading (FPT). 5,7-Dihydroxytryptamine (5,7-DHT) potentiated l-5-HTP-induced FBP but not HTW or FPT. Ritanserin interacted with 5-HT2 and 5-HT1c receptors. l-5-HTP-induced FBP could be mediated by postsynaptic 5-HT1c receptors and could serve as a behavioral model of postsynaptic 5-HT1c receptor stimulation in the CNS.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalEuropean Journal of Pharmacology
Volume169
Issue number1
DOIs
StatePublished - Oct 4 1989
Externally publishedYes

Keywords

  • 5,7-Dihydroxytryptamine (5,7-DHT)
  • 5-HT receptor
  • 5-HT syndrome
  • Ritanserin
  • l-5-Hydroxytryptophan (1-5-HTP)

ASJC Scopus subject areas

  • Pharmacology

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