l-5-Hydroxytryptophan (l-5-HTP)-induced flat body posture (FBP) was antagonized by ritanserin in doses that were lower than those needed to antagonize head-twitches (HTW) and forepaw treading (FPT). 5,7-Dihydroxytryptamine (5,7-DHT) potentiated l-5-HTP-induced FBP but not HTW or FPT. Ritanserin interacted with 5-HT2 and 5-HT1c receptors. l-5-HTP-induced FBP could be mediated by postsynaptic 5-HT1c receptors and could serve as a behavioral model of postsynaptic 5-HT1c receptor stimulation in the CNS.
- 5,7-Dihydroxytryptamine (5,7-DHT)
- 5-HT receptor
- 5-HT syndrome
- l-5-Hydroxytryptophan (1-5-HTP)
ASJC Scopus subject areas