Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Yoichi Nakao; Wesley Y. Yoshida; Yuuki Takada; Junji Kimura; Liu Yang; Susan L. Mooberry; Paul J. Scheuer

doi:10.1021/np049949f

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Yoichi Nakao, Wesley Y. Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L. Mooberry, Paul J. Scheuer

Pharmacology

Research output: Contribution to journal › Article

55 Scopus citations

Abstract

A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC₅₀ values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

Original language	English (US)
Pages (from-to)	1332-1340
Number of pages	9
Journal	Journal of Natural Products
Volume	67
Issue number	8
DOIs	https://doi.org/10.1021/np049949f
Publication status	Published - Aug 1 2004

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ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Cite this

Nakao, Y., Yoshida, W. Y., Takada, Y., Kimura, J., Yang, L., Mooberry, S. L., & Scheuer, P. J. (2004). Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa. Journal of Natural Products, 67(8), 1332-1340. https://doi.org/10.1021/np049949f

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10.1021/np049949f