Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Yoichi Nakao; Wesley Y. Yoshida; Yuuki Takada; Junji Kimura; Liu Yang; Susan L. Mooberry; Paul J. Scheuer

doi:10.1021/np049949f

Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

Yoichi Nakao, Wesley Y. Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L. Mooberry, Paul J. Scheuer

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC₅₀ values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

Original language	English (US)
Pages (from-to)	1332-1340
Number of pages	9
Journal	Journal of Natural Products
Volume	67
Issue number	8
DOIs	https://doi.org/10.1021/np049949f
State	Published - Aug 2004
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa",

abstract = "A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.",

author = "Yoichi Nakao and Yoshida, {Wesley Y.} and Yuuki Takada and Junji Kimura and Liu Yang and Mooberry, {Susan L.} and Scheuer, {Paul J.}",

year = "2004",

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doi = "10.1021/np049949f",

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volume = "67",

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publisher = "American Chemical Society",

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T1 - Kulokekahilide-2, a cytotoxic depsipeptide from a cephalaspidean mollusk Philinopsis Speciosa

AU - Nakao, Yoichi

AU - Yoshida, Wesley Y.

AU - Takada, Yuuki

AU - Kimura, Junji

AU - Yang, Liu

AU - Mooberry, Susan L.

AU - Scheuer, Paul J.

PY - 2004/8

Y1 - 2004/8

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AB - A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.

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