Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-β onto the hippocampus in vivo

Sergio Rosales-Corral, Dun Xian Tan, Russel J Reiter, Miguel Valdivia-Velázquez, J. Pablo Acosta-Martínez, Genaro G. Ortiz

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to describe - following the injection of a single intracerebral dose of fibrillar amyloid-β1-40 in vivo - some correlations between proinflammatory cytokines and oxidative stress indicators in function of time, as well as how these variables fit in a regression model. We found a positive, significant correlation between interleukin (IL)-1β or IL-6 and the activity of the glutathione peroxidase enzyme (GSH-Px), but IL-1β or IL-6 maintained a strong, negative correlation with the lipid peroxidation (LPO). The first 12 h marked a positive correlation between IL-6 and tumor necrosis factor-alpha (TNF-α), but starting from the 36 h, this relationship became negative. We found also particular patterns of behavior through the time for IL-1β, nitrites and IL-6, with parallel or sequential interrelationships. Results shows clearly that, in vivo, the fibrillar amyloid-β (Aβ) disrupts the oxidative balance and initiate a proinflammatory response, which in turn feeds the oxidative imbalance in a coordinated, sequential way. This work contributes to our understanding of the positive feedbacks, focusing the "cytokine cycle" along with the oxidative stress mediators in a complex, multicellular, and interactive environment.

Original languageEnglish (US)
Pages (from-to)20-28
Number of pages9
JournalJournal of Neuroimmunology
Volume150
Issue number1-2
DOIs
StatePublished - May 2004

Fingerprint

Amyloid
Interleukin-6
Hippocampus
Oxidative Stress
Interleukin-1
Injections
Brain
Cytokines
Glutathione Peroxidase
Nitrites
Lipid Peroxidation
Tumor Necrosis Factor-alpha
Enzymes

Keywords

  • Amyloid-β
  • Cytokine
  • Interleukin
  • Kinetics
  • Neuroinflammatory response
  • Oxidative stress
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-β onto the hippocampus in vivo. / Rosales-Corral, Sergio; Tan, Dun Xian; Reiter, Russel J; Valdivia-Velázquez, Miguel; Acosta-Martínez, J. Pablo; Ortiz, Genaro G.

In: Journal of Neuroimmunology, Vol. 150, No. 1-2, 05.2004, p. 20-28.

Research output: Contribution to journalArticle

Rosales-Corral, Sergio ; Tan, Dun Xian ; Reiter, Russel J ; Valdivia-Velázquez, Miguel ; Acosta-Martínez, J. Pablo ; Ortiz, Genaro G. / Kinetics of the neuroinflammation-oxidative stress correlation in rat brain following the injection of fibrillar amyloid-β onto the hippocampus in vivo. In: Journal of Neuroimmunology. 2004 ; Vol. 150, No. 1-2. pp. 20-28.
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