KIN17, a mouse nuclear protein, binds to bent DNA fragments that are found at illegitimate recombination junctions in mammalian cells

Alexander Mazin, Eric Milot, Raymond Devoret, Pierre Chartrand

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Illegitimate recombination is the dominant mechanism of recombination in mammalian somatic cells. It is responsible for most genome rearrangements such as translocations, deletions and integrations. Little is known as yet about the mechanism of illegitimate recombination and the enzymes involved. Recently, it has been shown that intrinsically bent DNA, also known as curved DNA, is present at chromosomal sites of illegitimate recombination events. Here we report that KIN17, a new mouse nuclear protein, binds to the curved DNA fragments found at illegitimate recombination sites.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalMGG Molecular & General Genetics
Volume244
Issue number4
DOIs
StatePublished - Jul 1994
Externally publishedYes

Keywords

  • Curved DNA
  • DNA rearrangements
  • DNA-binding proteins
  • Non-homologous recombination
  • Poly(A,T) tracts

ASJC Scopus subject areas

  • Genetics

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