Kidney transplantation during the first trimester of pregnancy: Immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone

Pablo E. Pergola, Asha Kancharla, Daniel J. Riley

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

We present a case of living, related-donor kidney transplantation during the first trimester of pregnancy. The patient received mycophenolate mofetil (MMF), tacrolimus, and prednisone throughout the entire pregnancy. This is the first reported case of use of MMF during pregnancy. The mother did well, except for mild preeclampsia and mild renal insufficiency at term. The baby girl was born prematurely at week 35 3/7. The only possible teratogenic effects detected included hypoplastic nails and short fifth fingers. No chromosomal abnormalities were found. The child is growing and developing normally. Although we do not recommend the use of mycophenolate mofetil during pregnancy based on this experience, it is reassuring to know that a successful outcome can be expected in mothers treated with MMF during pregnancy.

Original languageEnglish (US)
Pages (from-to)994-997
Number of pages4
JournalTransplantation
Volume71
Issue number7
DOIs
StatePublished - Apr 15 2001

ASJC Scopus subject areas

  • Transplantation

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