Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss; Mark P. Goldberg; Dennis W. Choi

doi:10.1016/0006-8993(86)91447-2

Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss
, Mark P. Goldberg
, Dennis W. Choi

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

Original language	English (US)
Pages (from-to)	186-190
Number of pages	5
Journal	Brain Research
Volume	380
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91447-2
State	Published - Aug 13 1986
Externally published	Yes

Keywords

cell culture
cell death
cyanide
glutamate
hypoxia
ketamine

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(86)91447-2

Cite this

@article{075aed5a9bee4623ab548ab8b94dcd6f,

title = "Ketamine protects cultured neocortical neurons from hypoxic injury",

abstract = "The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.",

keywords = "cell culture, cell death, cyanide, glutamate, hypoxia, ketamine",

author = "John Weiss and Goldberg, \{Mark P.\} and Choi, \{Dennis W.\}",

note = "Funding Information: Wills and Hereditary Disease Foundations, and by a Hartford Fellowship from the John A. Hartford Foundation (to D.W.C.). Funding Information: Yokoyama for expert assistance with cell cultures. Ketamine was a kind gift from Warner-Lambert. This research was supported by Grant NS21628 from the National Institute of Health, grants from the",

year = "1986",

month = aug,

day = "13",

doi = "10.1016/0006-8993(86)91447-2",

language = "English (US)",

volume = "380",

pages = "186--190",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Ketamine protects cultured neocortical neurons from hypoxic injury

AU - Weiss, John

AU - Goldberg, Mark P.

AU - Choi, Dennis W.

N1 - Funding Information: Wills and Hereditary Disease Foundations, and by a Hartford Fellowship from the John A. Hartford Foundation (to D.W.C.). Funding Information: Yokoyama for expert assistance with cell cultures. Ketamine was a kind gift from Warner-Lambert. This research was supported by Grant NS21628 from the National Institute of Health, grants from the

PY - 1986/8/13

Y1 - 1986/8/13

N2 - The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

AB - The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

KW - cell culture

KW - cell death

KW - cyanide

KW - glutamate

KW - hypoxia

KW - ketamine

UR - https://www.scopus.com/pages/publications/0022458644

UR - https://www.scopus.com/pages/publications/0022458644#tab=citedBy

U2 - 10.1016/0006-8993(86)91447-2

DO - 10.1016/0006-8993(86)91447-2

M3 - Article

C2 - 3756469

AN - SCOPUS:0022458644

SN - 0006-8993

VL - 380

SP - 186

EP - 190

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Ketamine protects cultured neocortical neurons from hypoxic injury

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this