Ketamine protects cultured neocortical neurons from hypoxic injury

John Weiss, Mark P. Goldberg, Dennis W. Choi

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalBrain Research
Issue number1
StatePublished - Aug 13 1986
Externally publishedYes


  • cell culture
  • cell death
  • cyanide
  • glutamate
  • hypoxia
  • ketamine

ASJC Scopus subject areas

  • Clinical Neurology
  • Molecular Biology
  • General Neuroscience
  • Developmental Biology


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