Abstract
The general anesthetic ketamine, which has recently been reported to block the excitation of cortical neurons by N-methyl-d-aspartate (NMDA), was found to markedly reduce neuronal loss in murine neocortical cell cultures exposed to a hypoxic atmosphere or to cyanide. These observations may be relevant to attempts to find pharmacological means of minimizing hypoxic brain damage in the clinical setting.
Original language | English (US) |
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Pages (from-to) | 186-190 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 380 |
Issue number | 1 |
DOIs | |
State | Published - Aug 13 1986 |
Externally published | Yes |
Keywords
- cell culture
- cell death
- cyanide
- glutamate
- hypoxia
- ketamine
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology