Keratoconus progression associated with hormone replacement therapy

Giulia Coco, A. Kheirkhah, William Foulsham, Reza Dana, Joseph B. Ciolino

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Purpose: To report a postmenopausal patient with keratoconus who experienced significant progression after using hormone replacement therapy. Observations: A 51-year-old woman with previously stable keratoconus presented with acute disease progression following hormone replacement therapy in the context of prophylactic hysterectomy and bilateral ovariosalpingectomy. Over a 14-month period after starting hormone therapy, the steepest K increased from 63.7D to 71.5D in the right eye and from 65.8D to 78.1D in the left eye. Conclusions: Hormone replacement therapy may amplify progression of keratoconus.

Original languageEnglish (US)
Article number100519
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Sep 2019
Externally publishedYes


  • Hormone replacement therapy
  • Keratoconus
  • Keratoconus progression

ASJC Scopus subject areas

  • Ophthalmology


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