Abstract
Hsp70s are ubiquitous chaperones that use ATP hydrolysis to drive a variety of protein processing reactions, including a number of steps in protein trafficking. Recent studies have shed light on how ATP might generate conformational changes in an Hsp70 molecule and how such changes might be harnessed to drive processes as diverse as protein import into subcellular organelles and uncoating of clathrin-coated vesicles.
Original language | English (US) |
---|---|
Pages (from-to) | 1596-1603 |
Number of pages | 8 |
Journal | Traffic |
Volume | 7 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2006 |
Keywords
- Chaperone
- Clathrin
- Coated vesicles
- Hsc70
- Hsp70
- Motor protein
- Protein import
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Structural Biology
- Biochemistry
- Cell Biology