Keep the traffic moving: Mechanism of the Hsp70 motor

Rui J Sousa, Eileen M. Lafer

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Hsp70s are ubiquitous chaperones that use ATP hydrolysis to drive a variety of protein processing reactions, including a number of steps in protein trafficking. Recent studies have shed light on how ATP might generate conformational changes in an Hsp70 molecule and how such changes might be harnessed to drive processes as diverse as protein import into subcellular organelles and uncoating of clathrin-coated vesicles.

Original languageEnglish (US)
Pages (from-to)1596-1603
Number of pages8
Issue number12
StatePublished - Dec 2006


  • Chaperone
  • Clathrin
  • Coated vesicles
  • Hsc70
  • Hsp70
  • Motor protein
  • Protein import

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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