TY - JOUR
T1 - Kappa receptor mediated opioid dependence in rhesus monkeys
AU - Gmerek, Debra E.
AU - Woods, James H.
N1 - Funding Information:
We thank Dr. James Collins (The Upjohn Company, Kalamazoo, MI) for the generous supply of U-50,488; and Me1 Dickerson and Fred Adams for their excellent technical assistance. This work was supported by USPHS grant DA 00254.
PY - 1986/9/15
Y1 - 1986/9/15
N2 - The kappa receptor-selective agonist U-50, 488 was administered chronically to rhesus monkeys. Tolerance developed to the overt behavioral effects of U-50, 488 without cross-tolerance to morphine. Withdrawal behaviors produced by deprivation, naloxone or quadazocine administration in U-50, 488-dependent monkeys consisted of hyperactivity, excessive grooming, and yawning. The syndrome was suppressed in a dose-related manner by a kappa agonist, ethylketazocine, but not by doses of morphine that suppressed its own withdrawal. The mu-selective antagonist, beta-funaltrexamine, at doses which are active in morphine-dependent monkeys, did not precipitate withdrawal in U50, 488-dependent monkeys. Dependence, which is the result of activity at the kappa receptor, was distinct from morphine dependence.
AB - The kappa receptor-selective agonist U-50, 488 was administered chronically to rhesus monkeys. Tolerance developed to the overt behavioral effects of U-50, 488 without cross-tolerance to morphine. Withdrawal behaviors produced by deprivation, naloxone or quadazocine administration in U-50, 488-dependent monkeys consisted of hyperactivity, excessive grooming, and yawning. The syndrome was suppressed in a dose-related manner by a kappa agonist, ethylketazocine, but not by doses of morphine that suppressed its own withdrawal. The mu-selective antagonist, beta-funaltrexamine, at doses which are active in morphine-dependent monkeys, did not precipitate withdrawal in U50, 488-dependent monkeys. Dependence, which is the result of activity at the kappa receptor, was distinct from morphine dependence.
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U2 - 10.1016/0024-3205(86)90287-0
DO - 10.1016/0024-3205(86)90287-0
M3 - Article
C2 - 3018406
AN - SCOPUS:0022508497
VL - 39
SP - 987
EP - 992
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 11
ER -