Job strain and cognitive decline: A prospective study of the framingham offspring cohort

Wilfred Agbenyikey, R. Karasek, M. Cifuentes, P. A. Wolf, S. Seshadri, J. A. Taylor, A. S. Beiser, R. Au

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Background: Workplace stress is known to be related with many behavioral and disease outcomes. However, little is known about its prospective relationship with measures of cogni­tive decline. Objective: To investigate the association of job strain, psychological demands and job con­trol on cognitive decline. Methods: Participants from Framingham Offspring cohort (n=1429), were assessed on job strain, and received neuropsychological assessment approximately 15 years and 21 years afterwards. Results: High job strain and low control were associated with decline in verbal learning and memory. Job strain was associated with decline in word recognition skills. Active job and passive job predicted decline in verbal learning and memory relative to low strain jobs in the younger subgroup. Active job and demands were positively associated with abstract reason­ing skills. Conclusions: Job strain and job control may influence decline in cognitive performance.

Original languageEnglish (US)
Pages (from-to)79-94
Number of pages16
JournalInternational Journal of Occupational and Environmental Medicine
Issue number2
StatePublished - 2015
Externally publishedYes


  • Active work
  • Cognition disorders
  • Job demand
  • Job strain
  • Passive work
  • Psychological
  • Stress
  • Work

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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