JC viruria is associated with reduced risk of diabetic kidney disease

Family Investigation of Nephropathy and Diabetes (FIND Consortium)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results: JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions: The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.

Original languageEnglish (US)
Pages (from-to)2286-2294
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume104
Issue number6
DOIs
StatePublished - Jun 1 2019
Externally publishedYes

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JC Virus
Diabetic Nephropathies
African Americans
BK Virus
Medical problems
Urine
Chronic Renal Insufficiency
Immune system
Immune System
Biomarkers
Diabetes Mellitus
Kidney
Polymerase Chain Reaction
Association reactions
Wounds and Injuries
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

JC viruria is associated with reduced risk of diabetic kidney disease. / Family Investigation of Nephropathy and Diabetes (FIND Consortium).

In: Journal of Clinical Endocrinology and Metabolism, Vol. 104, No. 6, 01.06.2019, p. 2286-2294.

Research output: Contribution to journalArticle

Family Investigation of Nephropathy and Diabetes (FIND Consortium) 2019, 'JC viruria is associated with reduced risk of diabetic kidney disease', Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 6, pp. 2286-2294. https://doi.org/10.1210/jc.2018-02482
Family Investigation of Nephropathy and Diabetes (FIND Consortium). / JC viruria is associated with reduced risk of diabetic kidney disease. In: Journal of Clinical Endocrinology and Metabolism. 2019 ; Vol. 104, No. 6. pp. 2286-2294.
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abstract = "Purpose: African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results: JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6{\%} vs 32.2{\%}; OR, 0.52; 95{\%} CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4{\%} vs 26.2{\%}; OR, 0.63; 95{\%} CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95{\%} CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions: The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.",
author = "{Family Investigation of Nephropathy and Diabetes (FIND Consortium)} and Etty Kruzel-Davila and Jasmin Divers and Russell, {Gregory B.} and Zipi Kra-Oz and Cohen, {Moran Szwarcwort} and Langefeld, {Carl D.} and Lijun Ma and Lyles, {Douglas S.} and Hicks, {Pamela J.} and Skorecki, {Karl L.} and Freedman, {Barry I.} and Iyengar, {S. K.} and Elston, {R. C.} and Goddard, {K. A.B.} and Olson, {J. M.} and S. Ialacci and J. Fondran and A. Horvath and R. Igo and G. Jun and K. Kramp and J. Molineros and Quade, {S. R.E.} and Sedor, {J. R.} and J. Schelling and A. Pickens and L. Humbert and L. Getz-Fradley and S. Adler and E. Ipp and M. Pahl and Seldin, {M. F.} and S. Snyder and J. Tayek and E. Hernandez and J. LaPage and C. Garcia and J. Gonzalez and M. Aguilar and M. Klag and R. Parekh and L. Kao and L. Meoni and T. Whitehead and J. Chester and Knowler, {W. C.} and Hanson, {R. L.} and Nelson, {R. G.} and J. Wolford and Kasinath, {Balakuntalam S}",
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TY - JOUR

T1 - JC viruria is associated with reduced risk of diabetic kidney disease

AU - Family Investigation of Nephropathy and Diabetes (FIND Consortium)

AU - Kruzel-Davila, Etty

AU - Divers, Jasmin

AU - Russell, Gregory B.

AU - Kra-Oz, Zipi

AU - Cohen, Moran Szwarcwort

AU - Langefeld, Carl D.

AU - Ma, Lijun

AU - Lyles, Douglas S.

AU - Hicks, Pamela J.

AU - Skorecki, Karl L.

AU - Freedman, Barry I.

AU - Iyengar, S. K.

AU - Elston, R. C.

AU - Goddard, K. A.B.

AU - Olson, J. M.

AU - Ialacci, S.

AU - Fondran, J.

AU - Horvath, A.

AU - Igo, R.

AU - Jun, G.

AU - Kramp, K.

AU - Molineros, J.

AU - Quade, S. R.E.

AU - Sedor, J. R.

AU - Schelling, J.

AU - Pickens, A.

AU - Humbert, L.

AU - Getz-Fradley, L.

AU - Adler, S.

AU - Ipp, E.

AU - Pahl, M.

AU - Seldin, M. F.

AU - Snyder, S.

AU - Tayek, J.

AU - Hernandez, E.

AU - LaPage, J.

AU - Garcia, C.

AU - Gonzalez, J.

AU - Aguilar, M.

AU - Klag, M.

AU - Parekh, R.

AU - Kao, L.

AU - Meoni, L.

AU - Whitehead, T.

AU - Chester, J.

AU - Knowler, W. C.

AU - Hanson, R. L.

AU - Nelson, R. G.

AU - Wolford, J.

AU - Kasinath, Balakuntalam S

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Purpose: African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results: JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions: The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.

AB - Purpose: African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results: JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions: The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.

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U2 - 10.1210/jc.2018-02482

DO - 10.1210/jc.2018-02482

M3 - Article

VL - 104

SP - 2286

EP - 2294

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -