Janus kinase Inhibition and its effect upon the therapeutic landscape for myelofibrosis: From palliation to cure?

Claire Harrison, Srdan Verstovsek, Mary F. Mcmullin, Ruben Mesa

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Following the discovery of the Janus kinase (JAK) 2 V617F mutation in 2005 the explosion of research and drug development activity has not only advanced our understanding of the pathogenesis of myeloproliferative neoplasms (MPNs) but also triggered debate about classification, allowed revised diagnostic and response criteria, provided a target for treatment and a mode of monitoring its success. These changes and the resultant clinical research are discussed in this article where we argue that discovery of the JAK2 V617F mutation has signalled the much delayed change in therapeutic paradigm for myelofibrosis and possibly other MPNs from palliation and allowing us to move closer to, but not yet attain, a cure.

Original languageEnglish (US)
Pages (from-to)426-437
Number of pages12
JournalBritish Journal of Haematology
Volume157
Issue number4
DOIs
StatePublished - May 1 2012
Externally publishedYes

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Keywords

  • Janus kinase 2
  • Janus kinase inhibitors
  • Myelofibrosis
  • Myeloproliferative neoplasms

ASJC Scopus subject areas

  • Hematology

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