Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma

Daruka Mahadevan, Gregory C. Rogers

Research output: Contribution to journalShort surveypeer-review

Abstract

Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalTrends in Cancer
Volume6
Issue number8
DOIs
StatePublished - Aug 2020

Keywords

  • aneuploidy
  • drug resistance
  • polyploidy
  • tetraploidy
  • tumor evolution

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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