JAK2 and genomic instability in the myeloproliferative neoplasms: A case of the chicken or the egg?

Linda M. Scott, Vivienne I. Rebel

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The myeloproliferative neoplasms (MPNs) are a particularly useful model for studying mutation accumulation in neoplastic cells, and the mechanisms underlying their acquisition. This review summarizes our current understanding of the molecular defects present in patients with an MPN, and the effects of mutations targeting Janus kinase 2 (JAK2)-mediated intracellular signaling on DNA damage and on the elimination of mutation-bearing cells by programmed cell death. Moreover, we discuss findings that suggest that the acquisition of disease-initiating mutations in hematopoietic stem cells of some MPN patients may be the consequence of an inherent genomic instability that was not previously appreciated.

Original languageEnglish (US)
Pages (from-to)1028-1036
Number of pages9
JournalAmerican Journal of Hematology
Volume87
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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