TY - JOUR
T1 - IV. Discriminative stimulus effects of narcotics
T2 - Evidence for multiple receptor-mediated actions
AU - Herling, Seymore
AU - Woods, James H.
N1 - Funding Information:
Preparation of this review was supported by USPHS Grants DA 00154 and DA 00254. We thank Gail Winger, Alice M. Young, Jonathan L. Katz, and Henry H. Swain for their helpful comments, and Elaine Sudman, Denise Gakle, and Isabel Herling for their assistance in preparing the manuscript.
PY - 1981/4/6
Y1 - 1981/4/6
N2 - Results of studies on the discriminative stimulus effects of narcotics are consistent with the hypothesis that multiple receptors mediate the effects of these compounds. In the rat, at least three subsets of discriminative effects exist, although some drugs appear to have effects that transcend more than one subset. The discriminative effects of morphine-like narcotics (μ agonists), for example, are often clearly distinguishable from the discriminative effects produced by κ agonists, such as ketazocine, and from those produced by phencyclidine-like agonists, such as SKF-10,047 and cyclazocine. Cyclazocine, however, has been reported to have discriminative effects in common with morphine (45) and fentanyl (17) and appears to have κ-like, in addition to phencyclidine-like, discriminative effects. The relative ability of pure narcotic antagonists to block the discriminative effects of these compounds also provides evidence for distinct pharmacologic actions of these drugs. In the rat, the discriminative effects of morphine are blocked by doses of naloxone that are considerably smaller than those that are needed to block the discriminative effects of cyclazocine (44). The discriminative effects of phencyclidine are not altered at all by naltrexone (63).
AB - Results of studies on the discriminative stimulus effects of narcotics are consistent with the hypothesis that multiple receptors mediate the effects of these compounds. In the rat, at least three subsets of discriminative effects exist, although some drugs appear to have effects that transcend more than one subset. The discriminative effects of morphine-like narcotics (μ agonists), for example, are often clearly distinguishable from the discriminative effects produced by κ agonists, such as ketazocine, and from those produced by phencyclidine-like agonists, such as SKF-10,047 and cyclazocine. Cyclazocine, however, has been reported to have discriminative effects in common with morphine (45) and fentanyl (17) and appears to have κ-like, in addition to phencyclidine-like, discriminative effects. The relative ability of pure narcotic antagonists to block the discriminative effects of these compounds also provides evidence for distinct pharmacologic actions of these drugs. In the rat, the discriminative effects of morphine are blocked by doses of naloxone that are considerably smaller than those that are needed to block the discriminative effects of cyclazocine (44). The discriminative effects of phencyclidine are not altered at all by naltrexone (63).
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U2 - 10.1016/0024-3205(81)90311-8
DO - 10.1016/0024-3205(81)90311-8
M3 - Article
C2 - 6264253
AN - SCOPUS:0019732807
VL - 28
SP - 1571
EP - 1584
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 14
ER -