Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Wesley J. Hoffmann, Ian McHardy, George R. Thompson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
Issue number5
StatePublished - May 2018
Externally publishedYes


  • hypertension
  • itraconazole
  • mineralocorticoid excess
  • side-effects

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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