Issues in the choice of genetic configuration for animal aging models

Steven N. Austad

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Animals used in aging research are generally of three genetic types- outbred, inbred, and hybrid. These three types have differing uses and characteristics. Outbred animals are heterozygous at many genetic loci and all individuals are genetically unique. Inbred animals are homozygous at all loci and genetically identical to one another. F1 hybrids are heterozygous at many loci, but genetically identical. Both theoretical and empirical findings suggest that each of these models behaves somewhat differently with respect to aging. This presentation will detail these theoretical and empirical findings, and suggest what uses each genetic type might best be put to with respect to aging research.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalExperimental Gerontology
Volume32
Issue number1-2
DOIs
StatePublished - Jan 1 1997

Keywords

  • animal models
  • genetic variation
  • inbreeding
  • outbreeding
  • uniformity

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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