Issues in the choice of genetic configuration for animal aging models

Steven N. Austad

doi:10.1016/S0531-5565(96)00033-2

Issues in the choice of genetic configuration for animal aging models

Steven N. Austad

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Animals used in aging research are generally of three genetic types- outbred, inbred, and hybrid. These three types have differing uses and characteristics. Outbred animals are heterozygous at many genetic loci and all individuals are genetically unique. Inbred animals are homozygous at all loci and genetically identical to one another. F₁ hybrids are heterozygous at many loci, but genetically identical. Both theoretical and empirical findings suggest that each of these models behaves somewhat differently with respect to aging. This presentation will detail these theoretical and empirical findings, and suggest what uses each genetic type might best be put to with respect to aging research.

Original language	English (US)
Pages (from-to)	55-63
Number of pages	9
Journal	Experimental Gerontology
Volume	32
Issue number	1-2
DOIs	https://doi.org/10.1016/S0531-5565(96)00033-2
State	Published - 1997

Keywords

animal models
genetic variation
inbreeding
outbreeding
uniformity

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/S0531-5565(96)00033-2

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title = "Issues in the choice of genetic configuration for animal aging models",

abstract = "Animals used in aging research are generally of three genetic types- outbred, inbred, and hybrid. These three types have differing uses and characteristics. Outbred animals are heterozygous at many genetic loci and all individuals are genetically unique. Inbred animals are homozygous at all loci and genetically identical to one another. F1 hybrids are heterozygous at many loci, but genetically identical. Both theoretical and empirical findings suggest that each of these models behaves somewhat differently with respect to aging. This presentation will detail these theoretical and empirical findings, and suggest what uses each genetic type might best be put to with respect to aging research.",

keywords = "animal models, genetic variation, inbreeding, outbreeding, uniformity",

author = "Austad, {Steven N.}",

note = "Funding Information: Acknowledgments--This work was partially funded by the National Instituteo n Aging, Grants AG11534 and AG09700.",

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AB - Animals used in aging research are generally of three genetic types- outbred, inbred, and hybrid. These three types have differing uses and characteristics. Outbred animals are heterozygous at many genetic loci and all individuals are genetically unique. Inbred animals are homozygous at all loci and genetically identical to one another. F1 hybrids are heterozygous at many loci, but genetically identical. Both theoretical and empirical findings suggest that each of these models behaves somewhat differently with respect to aging. This presentation will detail these theoretical and empirical findings, and suggest what uses each genetic type might best be put to with respect to aging research.

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Issues in the choice of genetic configuration for animal aging models

Abstract

Keywords

ASJC Scopus subject areas

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