Isoproterenol in offsetting adverse effects of vasopressin in cirrhotic patients

Kenneth R. Sirinek, Neil R. Thomford

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Vasopressin administered as a peripheral infusion (40 U/hr) significantly reduced portal vein pressure in ten awake patients with cirrhosis and portal hypertension. A vasopressin-induced reduction in cardiac output occurred in five of the ten patients (50 per cent). Vasopressin-induced changes in systemic arterial pressure, heart rate, and portal venous pressure were independent of alterations in cardiac output. When the five patients with vasopressin-induced reductions in cardiac output were given a combination of vasopressin and isoproterenol, cardiac output was maintained and the reduction in portal vein pressure was equal to that observed with unopposed vasopressin therapy. Thus, the addition of isoproterenol prevented a vasopressin-induced reduction in cardiac output while permitting vasopressin to reduce portal vein pressure.

Original languageEnglish (US)
Pages (from-to)130-136
Number of pages7
JournalThe American Journal of Surgery
Volume129
Issue number2
DOIs
StatePublished - Feb 1975
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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