Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria

Eric H. Andrianasolo; Harald Gross; Douglas Goeger; Mirjam Musafija-Girt; Kerry McPhail; Rachel M. Leal; Susan L. Mooberry; William H. Gerwick

doi:10.1021/ol050188x

Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria

Eric H. Andrianasolo, Harald Gross, Douglas Goeger, Mirjam Musafija-Girt, Kerry McPhail, Rachel M. Leal, Susan L. Mooberry, William H. Gerwick

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

(Chemical Equation Presented) Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.

Original language	English (US)
Pages (from-to)	1375-1378
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	7
DOIs	https://doi.org/10.1021/ol050188x
State	Published - Mar 31 2005

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol050188x

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abstract = "(Chemical Equation Presented) Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.",

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T1 - Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria

AU - Andrianasolo, Eric H.

AU - Gross, Harald

AU - Goeger, Douglas

AU - Musafija-Girt, Mirjam

AU - McPhail, Kerry

AU - Leal, Rachel M.

AU - Mooberry, Susan L.

AU - Gerwick, William H.

PY - 2005/3/31

Y1 - 2005/3/31

N2 - (Chemical Equation Presented) Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.

AB - (Chemical Equation Presented) Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.

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SN - 1523-7060

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Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria

Abstract

ASJC Scopus subject areas

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