Isolation of a Bacillus subtilis spoIIGA allele that suppresses processing-negative mutations in the Pro-σ(E) gene (sigE)

H. K. Peters, W. G. Haldenwang

Research output: Contribution to journalComment/debatepeer-review

23 Scopus citations

Abstract

σ(E), a sporulation-essential sigma factor of Bacillus subtilis, is formed by a developmentally regulated proteolysis which removes 27 to 29 amino acids from the amino terminus of an inactive precursor protein (Pro- σ(E)). A mutation which facilitates the conversion of inefficiently processed Pro-σ(E) variants into mature σ(E) was identified and mapped to spoIIGA. The isolation of such a mutation argues that SpoIIGA is directly involved in the Pro-σ(E) processing reaction.

Original languageEnglish (US)
Pages (from-to)7763-7766
Number of pages4
JournalJournal of bacteriology
Volume176
Issue number24
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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