Isolated vitamin E deficiency

Carlayne E. Jackson, Anthony A. Amato, Richard J. Barohn

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


A 22-year-old man presented with progressive gait instability, tremor, and dysarthria since childhood. Electrophysiologic studies revealed a sensorimotor polyneuropathy. Laboratory studies documented vitamin E deficiency; however, no gastrointestinal, hepatic, or lipoprotein disorder could be identified. Vitamin E therapy normalized the serum level, but there was no neurologic improvement. Isolated vitamin E deficiency, in the absence of lipid malabsorption, should be considered in the evaluation of children and adults with ataxia and peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalMuscle and Nerve
Issue number9
StatePublished - Sep 1996


  • ataxia
  • peripheral neuropathy
  • spinocerebellar degeneration
  • tocopherols
  • vitamin E deficiency

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Cellular and Molecular Neuroscience
  • Physiology


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