Isolated vaginal myeloid sarcoma in a 16-year-old girl

Maria Luisa C Policarpio-nicolas, Philip T. Valente, Gregory J. Aune, Russell A. Higgins

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Involvement of the female genital tract by myeloid sarcoma as the initial presentation is extremely uncommon, especially in the vagina. The lack of specific histologic features and the unusual location can be a diagnostic challenge to both the surgical pathologist and the clinician. The very few reported cases of myeloid sarcoma occurring in the vagina have been exclusively seen in adults. We report a 16-year-old girl who presented with a vaginal mass of 4 weeks duration. The initial clinical impression was a Bartholin cyst vs an abscess. However, because of persistence of the vaginal mass after a full course of antibiotic treatment, a biopsy was performed. Immunohistochemistry supported the diagnosis of myeloid sarcoma. Peripheral blood and bone marrow studies were normal. The patient received 4 cycles of chemotherapy and remained disease free 5 months from therapy completion. The clinical course, diagnostic workup, and differential diagnosis of our patient are discussed. Reported cases of myeloid sarcoma occurring in the vagina are reviewed and summarized.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalAnnals of Diagnostic Pathology
Issue number5
StatePublished - Oct 2012


  • Adolescent
  • Isolated myeloid sarcoma
  • Vagina

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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