Isolated penile ulceration after Nivolumab therapy for non-small cell lung carcinoma

Gina T. Baaklini; Misty J. Thompson; Kevin J. Krauland; Daniel R. Walker; Steven J. Hudak

doi:10.1016/j.eucr.2020.101339

Isolated penile ulceration after Nivolumab therapy for non-small cell lung carcinoma

Gina T. Baaklini, Misty J. Thompson, Kevin J. Krauland, Daniel R. Walker, Steven J. Hudak

Department of Urology

Research output: Contribution to journal › Article › peer-review

Abstract

Immune-related cutaneous events can develop after immunotherapy. To our knowledge, we present the first reported case of isolated focal penile inflammatory ulceration in a patient being treated with Nivolumab for stage IV non-small cell lung carcinoma. He presented with a painless penile ulceration two months after initiating therapy. He had near-complete resolution of his ulcer after two weeks of topical treatment. Histologic evaluation revealed a drug eruption. While cutaneous events are a well-known side effect of immunotherapy, this is the first report of an isolated penile lesion from such therapy.

Original language	English (US)
Article number	101339
Journal	Urology Case Reports
Volume	33
DOIs	https://doi.org/10.1016/j.eucr.2020.101339
State	Published - Nov 2020

Keywords

Drug eruption
Immunotherapy
Nivolumab
Penile ulceration

ASJC Scopus subject areas

Urology

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10.1016/j.eucr.2020.101339

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title = "Isolated penile ulceration after Nivolumab therapy for non-small cell lung carcinoma",

abstract = "Immune-related cutaneous events can develop after immunotherapy. To our knowledge, we present the first reported case of isolated focal penile inflammatory ulceration in a patient being treated with Nivolumab for stage IV non-small cell lung carcinoma. He presented with a painless penile ulceration two months after initiating therapy. He had near-complete resolution of his ulcer after two weeks of topical treatment. Histologic evaluation revealed a drug eruption. While cutaneous events are a well-known side effect of immunotherapy, this is the first report of an isolated penile lesion from such therapy.",

keywords = "Drug eruption, Immunotherapy, Nivolumab, Penile ulceration",

author = "Baaklini, {Gina T.} and Thompson, {Misty J.} and Krauland, {Kevin J.} and Walker, {Daniel R.} and Hudak, {Steven J.}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

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AU - Baaklini, Gina T.

AU - Thompson, Misty J.

AU - Krauland, Kevin J.

AU - Walker, Daniel R.

AU - Hudak, Steven J.

PY - 2020/11

Y1 - 2020/11

N2 - Immune-related cutaneous events can develop after immunotherapy. To our knowledge, we present the first reported case of isolated focal penile inflammatory ulceration in a patient being treated with Nivolumab for stage IV non-small cell lung carcinoma. He presented with a painless penile ulceration two months after initiating therapy. He had near-complete resolution of his ulcer after two weeks of topical treatment. Histologic evaluation revealed a drug eruption. While cutaneous events are a well-known side effect of immunotherapy, this is the first report of an isolated penile lesion from such therapy.

AB - Immune-related cutaneous events can develop after immunotherapy. To our knowledge, we present the first reported case of isolated focal penile inflammatory ulceration in a patient being treated with Nivolumab for stage IV non-small cell lung carcinoma. He presented with a painless penile ulceration two months after initiating therapy. He had near-complete resolution of his ulcer after two weeks of topical treatment. Histologic evaluation revealed a drug eruption. While cutaneous events are a well-known side effect of immunotherapy, this is the first report of an isolated penile lesion from such therapy.

KW - Drug eruption

KW - Immunotherapy

KW - Nivolumab

KW - Penile ulceration

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Isolated penile ulceration after Nivolumab therapy for non-small cell lung carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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