Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections

Miriam Weinberger, I. Mahrshak, N. Keller, A. Goldscmied-Reuven, N. Amariglio, M. Kramer, A. Tobar, Z. Samra, S. D. Pitlik, M. G. Rinaldi, E. Thompson, D. Sutton

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We report a case of endogenous endophthalmitis due to a sporodochial-forming species of Phialemonium curvatum. The infection led to the enucleation of the affected eye, but there was no evidence of systemic dissemination. The isolated P. curvatum produced aggregates of phialides, many occurring on coils or in verticils, which eventually develop into sporodochia. The initial and post-enucleation isolates revealed they were identical to strains of P. curvatum from Israel causing disseminated disease in patients practicing intracavernous autoinjections for the treatment of erectile dysfunction. The reported case had unusual clinical and microbiological features. Despite the route of acquisition and the lack of systemic antifungal therapy, the infection did not spread beyond the eye. The morphology of the phialides aggregates was also unique, and the distinction between Volutella and Acremonium is discussed. This case expands the spectrum of infections due to Phialemonium species, and reveals a novel way of developing fungal endophthalmitis.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalMedical mycology
Volume44
Issue number3
DOIs
StatePublished - May 2006

Keywords

  • Contamination
  • Endophthalmitis
  • Injections
  • Outbreak
  • Phialemonium curvatum

ASJC Scopus subject areas

  • Infectious Diseases

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