Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections

Miriam Weinberger, I. Mahrshak, N. Keller, A. Goldscmied-Reuven, N. Amariglio, M. Kramer, A. Tobar, Z. Samra, S. D. Pitlik, M. G. Rinaldi, E. Thompson, D. Sutton

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We report a case of endogenous endophthalmitis due to a sporodochial-forming species of Phialemonium curvatum. The infection led to the enucleation of the affected eye, but there was no evidence of systemic dissemination. The isolated P. curvatum produced aggregates of phialides, many occurring on coils or in verticils, which eventually develop into sporodochia. The initial and post-enucleation isolates revealed they were identical to strains of P. curvatum from Israel causing disseminated disease in patients practicing intracavernous autoinjections for the treatment of erectile dysfunction. The reported case had unusual clinical and microbiological features. Despite the route of acquisition and the lack of systemic antifungal therapy, the infection did not spread beyond the eye. The morphology of the phialides aggregates was also unique, and the distinction between Volutella and Acremonium is discussed. This case expands the spectrum of infections due to Phialemonium species, and reveals a novel way of developing fungal endophthalmitis.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalMedical Mycology
Volume44
Issue number3
DOIs
StatePublished - May 2006

Fingerprint

Endophthalmitis
Infection
eyes
Eye Enucleation
infection
Acremonium
Erectile Dysfunction
Israel
case studies
therapeutics
Therapeutics

Keywords

  • Contamination
  • Endophthalmitis
  • Injections
  • Outbreak
  • Phialemonium curvatum

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

Weinberger, M., Mahrshak, I., Keller, N., Goldscmied-Reuven, A., Amariglio, N., Kramer, M., ... Sutton, D. (2006). Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections. Medical Mycology, 44(3), 253-259. https://doi.org/10.1080/13693780500411097

Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections. / Weinberger, Miriam; Mahrshak, I.; Keller, N.; Goldscmied-Reuven, A.; Amariglio, N.; Kramer, M.; Tobar, A.; Samra, Z.; Pitlik, S. D.; Rinaldi, M. G.; Thompson, E.; Sutton, D.

In: Medical Mycology, Vol. 44, No. 3, 05.2006, p. 253-259.

Research output: Contribution to journalArticle

Weinberger, M, Mahrshak, I, Keller, N, Goldscmied-Reuven, A, Amariglio, N, Kramer, M, Tobar, A, Samra, Z, Pitlik, SD, Rinaldi, MG, Thompson, E & Sutton, D 2006, 'Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections', Medical Mycology, vol. 44, no. 3, pp. 253-259. https://doi.org/10.1080/13693780500411097
Weinberger, Miriam ; Mahrshak, I. ; Keller, N. ; Goldscmied-Reuven, A. ; Amariglio, N. ; Kramer, M. ; Tobar, A. ; Samra, Z. ; Pitlik, S. D. ; Rinaldi, M. G. ; Thompson, E. ; Sutton, D. / Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections. In: Medical Mycology. 2006 ; Vol. 44, No. 3. pp. 253-259.
@article{74d34dc854e04552ae927d36476ee555,
title = "Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections",
abstract = "We report a case of endogenous endophthalmitis due to a sporodochial-forming species of Phialemonium curvatum. The infection led to the enucleation of the affected eye, but there was no evidence of systemic dissemination. The isolated P. curvatum produced aggregates of phialides, many occurring on coils or in verticils, which eventually develop into sporodochia. The initial and post-enucleation isolates revealed they were identical to strains of P. curvatum from Israel causing disseminated disease in patients practicing intracavernous autoinjections for the treatment of erectile dysfunction. The reported case had unusual clinical and microbiological features. Despite the route of acquisition and the lack of systemic antifungal therapy, the infection did not spread beyond the eye. The morphology of the phialides aggregates was also unique, and the distinction between Volutella and Acremonium is discussed. This case expands the spectrum of infections due to Phialemonium species, and reveals a novel way of developing fungal endophthalmitis.",
keywords = "Contamination, Endophthalmitis, Injections, Outbreak, Phialemonium curvatum",
author = "Miriam Weinberger and I. Mahrshak and N. Keller and A. Goldscmied-Reuven and N. Amariglio and M. Kramer and A. Tobar and Z. Samra and Pitlik, {S. D.} and Rinaldi, {M. G.} and E. Thompson and D. Sutton",
year = "2006",
month = "5",
doi = "10.1080/13693780500411097",
language = "English (US)",
volume = "44",
pages = "253--259",
journal = "Medical Mycology",
issn = "1369-3786",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Isolated endogenous endophthalmitis due to a sporodochial-forming Phialemonium curvatum acquired through intracavernous autoinjections

AU - Weinberger, Miriam

AU - Mahrshak, I.

AU - Keller, N.

AU - Goldscmied-Reuven, A.

AU - Amariglio, N.

AU - Kramer, M.

AU - Tobar, A.

AU - Samra, Z.

AU - Pitlik, S. D.

AU - Rinaldi, M. G.

AU - Thompson, E.

AU - Sutton, D.

PY - 2006/5

Y1 - 2006/5

N2 - We report a case of endogenous endophthalmitis due to a sporodochial-forming species of Phialemonium curvatum. The infection led to the enucleation of the affected eye, but there was no evidence of systemic dissemination. The isolated P. curvatum produced aggregates of phialides, many occurring on coils or in verticils, which eventually develop into sporodochia. The initial and post-enucleation isolates revealed they were identical to strains of P. curvatum from Israel causing disseminated disease in patients practicing intracavernous autoinjections for the treatment of erectile dysfunction. The reported case had unusual clinical and microbiological features. Despite the route of acquisition and the lack of systemic antifungal therapy, the infection did not spread beyond the eye. The morphology of the phialides aggregates was also unique, and the distinction between Volutella and Acremonium is discussed. This case expands the spectrum of infections due to Phialemonium species, and reveals a novel way of developing fungal endophthalmitis.

AB - We report a case of endogenous endophthalmitis due to a sporodochial-forming species of Phialemonium curvatum. The infection led to the enucleation of the affected eye, but there was no evidence of systemic dissemination. The isolated P. curvatum produced aggregates of phialides, many occurring on coils or in verticils, which eventually develop into sporodochia. The initial and post-enucleation isolates revealed they were identical to strains of P. curvatum from Israel causing disseminated disease in patients practicing intracavernous autoinjections for the treatment of erectile dysfunction. The reported case had unusual clinical and microbiological features. Despite the route of acquisition and the lack of systemic antifungal therapy, the infection did not spread beyond the eye. The morphology of the phialides aggregates was also unique, and the distinction between Volutella and Acremonium is discussed. This case expands the spectrum of infections due to Phialemonium species, and reveals a novel way of developing fungal endophthalmitis.

KW - Contamination

KW - Endophthalmitis

KW - Injections

KW - Outbreak

KW - Phialemonium curvatum

UR - http://www.scopus.com/inward/record.url?scp=33646843768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646843768&partnerID=8YFLogxK

U2 - 10.1080/13693780500411097

DO - 10.1080/13693780500411097

M3 - Article

C2 - 16702105

AN - SCOPUS:33646843768

VL - 44

SP - 253

EP - 259

JO - Medical Mycology

JF - Medical Mycology

SN - 1369-3786

IS - 3

ER -