Abstract
Phenylpropanolamine (PPA) suppresses appetite in rats via activation of α1-adrenergic receptors within the paraventricular hypothalamus (PVN). The serotonergic (5-HT) agonist fenfluramine (FEN) is thought to suppress appetite via stimulation of 5-HT release within the PVN rather than activation of adrenergic receptors. Whether a mixture of these neurochemically distinct anorexic drugs will serve as an effective appetite suppressant is unknown. In the present experiment, drug-drug interactions between PPA and FEN were explored using an isobologram technique. Fixed doses of PPA (0 vs. 5 mg/kg) were combined with various doses of FEN (1.25, 2.5, and 5.0 mg/kg) and fixed doses of FEN (0 vs. 2.5 mg/kg) were combined with various doses of PPA (0, 5, 10, and 15 mg/kg). Drug combinations were injected IP 30 min before a 1-h feeding trial in 16-h food-deprived rats. PPA and FEN were dose-additive in this paradigm, an outcome that supports the feasibility of a new appetite suppressant composed of a mixture of PPA and FEN.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 287-291 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 50 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- Anorexia
- Feeding
- Fenfluramine
- Paraventricular hypothalamus
- Phenylpropanolamine
- Serotonin
- α-Adrenoceptors
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Behavioral Neuroscience
- Biological Psychiatry
- Pharmacology
- Toxicology
Cite this
Isobolographic assessment of the effects of combinations of phenylpropanolamine and fenfluramine on food intake in rats. / Wellman, Paul J.; Tow, Sharon; McMahon, Lance.
In: Pharmacology, Biochemistry and Behavior, Vol. 50, No. 2, 1995, p. 287-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isobolographic assessment of the effects of combinations of phenylpropanolamine and fenfluramine on food intake in rats
AU - Wellman, Paul J.
AU - Tow, Sharon
AU - McMahon, Lance
PY - 1995
Y1 - 1995
N2 - Phenylpropanolamine (PPA) suppresses appetite in rats via activation of α1-adrenergic receptors within the paraventricular hypothalamus (PVN). The serotonergic (5-HT) agonist fenfluramine (FEN) is thought to suppress appetite via stimulation of 5-HT release within the PVN rather than activation of adrenergic receptors. Whether a mixture of these neurochemically distinct anorexic drugs will serve as an effective appetite suppressant is unknown. In the present experiment, drug-drug interactions between PPA and FEN were explored using an isobologram technique. Fixed doses of PPA (0 vs. 5 mg/kg) were combined with various doses of FEN (1.25, 2.5, and 5.0 mg/kg) and fixed doses of FEN (0 vs. 2.5 mg/kg) were combined with various doses of PPA (0, 5, 10, and 15 mg/kg). Drug combinations were injected IP 30 min before a 1-h feeding trial in 16-h food-deprived rats. PPA and FEN were dose-additive in this paradigm, an outcome that supports the feasibility of a new appetite suppressant composed of a mixture of PPA and FEN.
AB - Phenylpropanolamine (PPA) suppresses appetite in rats via activation of α1-adrenergic receptors within the paraventricular hypothalamus (PVN). The serotonergic (5-HT) agonist fenfluramine (FEN) is thought to suppress appetite via stimulation of 5-HT release within the PVN rather than activation of adrenergic receptors. Whether a mixture of these neurochemically distinct anorexic drugs will serve as an effective appetite suppressant is unknown. In the present experiment, drug-drug interactions between PPA and FEN were explored using an isobologram technique. Fixed doses of PPA (0 vs. 5 mg/kg) were combined with various doses of FEN (1.25, 2.5, and 5.0 mg/kg) and fixed doses of FEN (0 vs. 2.5 mg/kg) were combined with various doses of PPA (0, 5, 10, and 15 mg/kg). Drug combinations were injected IP 30 min before a 1-h feeding trial in 16-h food-deprived rats. PPA and FEN were dose-additive in this paradigm, an outcome that supports the feasibility of a new appetite suppressant composed of a mixture of PPA and FEN.
KW - Anorexia
KW - Feeding
KW - Fenfluramine
KW - Paraventricular hypothalamus
KW - Phenylpropanolamine
KW - Serotonin
KW - α-Adrenoceptors
UR - http://www.scopus.com/inward/record.url?scp=0028893275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028893275&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(94)00316-B
DO - 10.1016/0091-3057(94)00316-B
M3 - Article
C2 - 7740069
AN - SCOPUS:0028893275
VL - 50
SP - 287
EP - 291
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 2
ER -