Ischemic acute renal failure in the rat: protective effect of uninephrectomy.

T. A. Fried, A. Hishida, J. L. Barnes, J. H. Stein

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Abstract

Experiments were performed to investigate the effect 2-wk prior nephrectomy has on the recovery from a 40-min renal artery occlusion. Two groups were initially examined. Group 1 animals underwent sham nephrectomy and group 2 animals right nephrectomy 14 days prior to a 40-min left renal artery clamp. The percent recovery of inulin clearance in group 2 (33 +/- 6%) was not significantly different from that in the group 1 (36 +/- 8%) when measured 3 h after reflow. At 24 and 48 h of reflow, however, group 2 animals had a significantly higher percent recovery of inulin clearance (24 h: 31 +/- 5%; 48 h: 50 +/- 11%) than group 1 animals (24 h: 1 +/- 1%; 48 h: 8 +/- 4%). Similarly the histology was better preserved at 24 and 48 h in group 2. To further investigate this enhanced recovery, three additional groups were studied. Group 3 underwent right nephrectomy at the time of renal artery occlusion. Group 4 had right uretero-venostomies created immediately prior to the ischemic insult, and group 5 had their aortas rather than left renal arteries clamped. Each group shared with group 2, ischemia to all functioning excretory tissue. The percent recovery of inulin clearance in group 3 (48 +/- 9%), group 4 (54 +/- 5%), and group 5 (42 +/- 6%) were each significantly (P less than 0.005) higher than in group 1 (8 +/- 4%) when measured at 48 h. We conclude that the protection offered by uninephrectomy is not a consequence of hypertrophy but that alterations in the environment which follow ischemia to all functioning excretory renal tissue are responsible for the enhanced recovery seen.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume247
Issue number4 Pt 2
StatePublished - Oct 1984

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Renal Artery
Nephrectomy
Acute Kidney Injury
Inulin
Venous Cutdown
Ischemia
Animal Rights
Hypertrophy
Aorta
Histology
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fried, T. A., Hishida, A., Barnes, J. L., & Stein, J. H. (1984). Ischemic acute renal failure in the rat: protective effect of uninephrectomy. The American journal of physiology, 247(4 Pt 2).

Ischemic acute renal failure in the rat : protective effect of uninephrectomy. / Fried, T. A.; Hishida, A.; Barnes, J. L.; Stein, J. H.

In: The American journal of physiology, Vol. 247, No. 4 Pt 2, 10.1984.

Research output: Contribution to journalArticle

Fried, TA, Hishida, A, Barnes, JL & Stein, JH 1984, 'Ischemic acute renal failure in the rat: protective effect of uninephrectomy.', The American journal of physiology, vol. 247, no. 4 Pt 2.
Fried, T. A. ; Hishida, A. ; Barnes, J. L. ; Stein, J. H. / Ischemic acute renal failure in the rat : protective effect of uninephrectomy. In: The American journal of physiology. 1984 ; Vol. 247, No. 4 Pt 2.
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abstract = "Experiments were performed to investigate the effect 2-wk prior nephrectomy has on the recovery from a 40-min renal artery occlusion. Two groups were initially examined. Group 1 animals underwent sham nephrectomy and group 2 animals right nephrectomy 14 days prior to a 40-min left renal artery clamp. The percent recovery of inulin clearance in group 2 (33 +/- 6{\%}) was not significantly different from that in the group 1 (36 +/- 8{\%}) when measured 3 h after reflow. At 24 and 48 h of reflow, however, group 2 animals had a significantly higher percent recovery of inulin clearance (24 h: 31 +/- 5{\%}; 48 h: 50 +/- 11{\%}) than group 1 animals (24 h: 1 +/- 1{\%}; 48 h: 8 +/- 4{\%}). Similarly the histology was better preserved at 24 and 48 h in group 2. To further investigate this enhanced recovery, three additional groups were studied. Group 3 underwent right nephrectomy at the time of renal artery occlusion. Group 4 had right uretero-venostomies created immediately prior to the ischemic insult, and group 5 had their aortas rather than left renal arteries clamped. Each group shared with group 2, ischemia to all functioning excretory tissue. The percent recovery of inulin clearance in group 3 (48 +/- 9{\%}), group 4 (54 +/- 5{\%}), and group 5 (42 +/- 6{\%}) were each significantly (P less than 0.005) higher than in group 1 (8 +/- 4{\%}) when measured at 48 h. We conclude that the protection offered by uninephrectomy is not a consequence of hypertrophy but that alterations in the environment which follow ischemia to all functioning excretory renal tissue are responsible for the enhanced recovery seen.",
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