Isavuconazole is effective for the treatment of experimental cryptococcal meningitis

Nathan Wiederhold, Laura Kovanda, Laura K. Najvar, Rosie Bocanegra, Marcos Olivo, William R. Kirkpatrick, Thomas F Patterson

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We evaluated the efficacy of isavuconazole against cryptococcal meningitis. Treatment with either oral isavuconazole (120 mg/kg and 240 mg/kg twice a day [BID]) or fluconazole as the positive control significantly improved survival in mice infected intracranially with either Cryptococcus neoformans USC1597 or H99 and significantly reduced brain fungal burdens for both isolates. Concentrations of isavuconazole in plasma and brain tissue also demonstrated that the greatest improvements in survival and fungal burden were associated with elevated exposures.

Original languageEnglish (US)
Pages (from-to)5600-5603
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number9
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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  • Cite this

    Wiederhold, N., Kovanda, L., Najvar, L. K., Bocanegra, R., Olivo, M., Kirkpatrick, W. R., & Patterson, T. F. (2016). Isavuconazole is effective for the treatment of experimental cryptococcal meningitis. Antimicrobial Agents and Chemotherapy, 60(9), 5600-5603. https://doi.org/10.1128/AAC.00229-16