Is there an alternative to the cytoplasmic receptor model for the mechanism of action of steroids?

Peter J. Sheridan

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The essential features of the cytoplasmic receptor model for the mechanism of action of steroids are summarized and the restrictions imposed by such a model are noted. The literature which is not compatible with these restrictions is reviewed, and the necessity for a more general model discussed. A model for the mechanism of steroid action is proposed in which both specificity and saturability of binding in target tissue is both a function of cytoplasmic receptors and nuclear acceptors.

Original languageEnglish (US)
Pages (from-to)497-502
Number of pages6
JournalLife Sciences
Volume17
Issue number4
DOIs
StatePublished - Aug 15 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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