Is there a role for body mass index in the assessment of prostate cancer risk on biopsy?

Yuanyuan Liang, Norma S. Ketchum, Phyllis J. Goodman, Eric A. Klein, Ian M. Thompson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose We examine the role of body mass index in the assessment of prostate cancer risk. Materials and Methods A total of 3,258 participants who underwent biopsy (including 1,902 men with a diagnosis of prostate cancer) were identified from the Selenium and Vitamin E Cancer Prevention Trial. The associations of body mass index with prostate cancer and high grade prostate cancer were examined using logistic regression, adjusting for age, race, body mass index adjusted prostate specific antigen, digital rectal examination, family history of prostate cancer, biopsy history, prostate specific antigen velocity, and time between study entry and the last biopsy. The prediction models were compared with our previously developed body mass index adjusted Prostate Cancer Prevention Trial prostate cancer risk calculator. Results Of the study subjects 49.1% were overweight and 29.3% were obese. After adjustment, among men without a known family history of prostate cancer, increased body mass index was not associated with a higher risk of prostate cancer (per one-unit increase in logBMI OR 0.83, p=0.54) but was significantly associated with a higher risk of high grade prostate cancer (ie Gleason score 7 or greater prostate cancer) (OR 2.31, p=0.03). For men with a known family history of prostate cancer the risks of prostate cancer and high grade prostate cancer increased rapidly as body mass index increased (prostate cancer OR 3.73, p=0.02; high grade prostate cancer OR 7.95, p=0.002). The previously developed risk calculator generally underestimated the risks of prostate cancer and high grade prostate cancer. Conclusions Body mass index provided independently predictive information regarding the risks of prostate cancer and high grade prostate cancer after adjusting for other risk factors. Body mass index, especially in men with a known family history of prostate cancer, should be considered for inclusion in any clinical assessment of prostate cancer risk and recommendations regarding prostate biopsy.

Original languageEnglish (US)
Pages (from-to)1094-1099
Number of pages6
JournalJournal of Urology
Volume192
Issue number4
DOIs
StatePublished - Oct 1 2014

Fingerprint

Prostatic Neoplasms
Body Mass Index
Biopsy
Prostate-Specific Antigen
Social Adjustment
Digital Rectal Examination
Neoplasm Grading
Selenium
Vitamin E

Keywords

  • body mass index
  • neoplasm grading
  • prostate-specific antigen
  • prostatic neoplasms
  • risk factors

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Liang, Y., Ketchum, N. S., Goodman, P. J., Klein, E. A., & Thompson, I. M. (2014). Is there a role for body mass index in the assessment of prostate cancer risk on biopsy? Journal of Urology, 192(4), 1094-1099. https://doi.org/10.1016/j.juro.2014.04.015

Is there a role for body mass index in the assessment of prostate cancer risk on biopsy? / Liang, Yuanyuan; Ketchum, Norma S.; Goodman, Phyllis J.; Klein, Eric A.; Thompson, Ian M.

In: Journal of Urology, Vol. 192, No. 4, 01.10.2014, p. 1094-1099.

Research output: Contribution to journalArticle

Liang, Y, Ketchum, NS, Goodman, PJ, Klein, EA & Thompson, IM 2014, 'Is there a role for body mass index in the assessment of prostate cancer risk on biopsy?', Journal of Urology, vol. 192, no. 4, pp. 1094-1099. https://doi.org/10.1016/j.juro.2014.04.015
Liang, Yuanyuan ; Ketchum, Norma S. ; Goodman, Phyllis J. ; Klein, Eric A. ; Thompson, Ian M. / Is there a role for body mass index in the assessment of prostate cancer risk on biopsy?. In: Journal of Urology. 2014 ; Vol. 192, No. 4. pp. 1094-1099.
@article{03c552f786d84570ad81019ddfa79656,
title = "Is there a role for body mass index in the assessment of prostate cancer risk on biopsy?",
abstract = "Purpose We examine the role of body mass index in the assessment of prostate cancer risk. Materials and Methods A total of 3,258 participants who underwent biopsy (including 1,902 men with a diagnosis of prostate cancer) were identified from the Selenium and Vitamin E Cancer Prevention Trial. The associations of body mass index with prostate cancer and high grade prostate cancer were examined using logistic regression, adjusting for age, race, body mass index adjusted prostate specific antigen, digital rectal examination, family history of prostate cancer, biopsy history, prostate specific antigen velocity, and time between study entry and the last biopsy. The prediction models were compared with our previously developed body mass index adjusted Prostate Cancer Prevention Trial prostate cancer risk calculator. Results Of the study subjects 49.1{\%} were overweight and 29.3{\%} were obese. After adjustment, among men without a known family history of prostate cancer, increased body mass index was not associated with a higher risk of prostate cancer (per one-unit increase in logBMI OR 0.83, p=0.54) but was significantly associated with a higher risk of high grade prostate cancer (ie Gleason score 7 or greater prostate cancer) (OR 2.31, p=0.03). For men with a known family history of prostate cancer the risks of prostate cancer and high grade prostate cancer increased rapidly as body mass index increased (prostate cancer OR 3.73, p=0.02; high grade prostate cancer OR 7.95, p=0.002). The previously developed risk calculator generally underestimated the risks of prostate cancer and high grade prostate cancer. Conclusions Body mass index provided independently predictive information regarding the risks of prostate cancer and high grade prostate cancer after adjusting for other risk factors. Body mass index, especially in men with a known family history of prostate cancer, should be considered for inclusion in any clinical assessment of prostate cancer risk and recommendations regarding prostate biopsy.",
keywords = "body mass index, neoplasm grading, prostate-specific antigen, prostatic neoplasms, risk factors",
author = "Yuanyuan Liang and Ketchum, {Norma S.} and Goodman, {Phyllis J.} and Klein, {Eric A.} and Thompson, {Ian M.}",
year = "2014",
month = "10",
day = "1",
doi = "10.1016/j.juro.2014.04.015",
language = "English (US)",
volume = "192",
pages = "1094--1099",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Is there a role for body mass index in the assessment of prostate cancer risk on biopsy?

AU - Liang, Yuanyuan

AU - Ketchum, Norma S.

AU - Goodman, Phyllis J.

AU - Klein, Eric A.

AU - Thompson, Ian M.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Purpose We examine the role of body mass index in the assessment of prostate cancer risk. Materials and Methods A total of 3,258 participants who underwent biopsy (including 1,902 men with a diagnosis of prostate cancer) were identified from the Selenium and Vitamin E Cancer Prevention Trial. The associations of body mass index with prostate cancer and high grade prostate cancer were examined using logistic regression, adjusting for age, race, body mass index adjusted prostate specific antigen, digital rectal examination, family history of prostate cancer, biopsy history, prostate specific antigen velocity, and time between study entry and the last biopsy. The prediction models were compared with our previously developed body mass index adjusted Prostate Cancer Prevention Trial prostate cancer risk calculator. Results Of the study subjects 49.1% were overweight and 29.3% were obese. After adjustment, among men without a known family history of prostate cancer, increased body mass index was not associated with a higher risk of prostate cancer (per one-unit increase in logBMI OR 0.83, p=0.54) but was significantly associated with a higher risk of high grade prostate cancer (ie Gleason score 7 or greater prostate cancer) (OR 2.31, p=0.03). For men with a known family history of prostate cancer the risks of prostate cancer and high grade prostate cancer increased rapidly as body mass index increased (prostate cancer OR 3.73, p=0.02; high grade prostate cancer OR 7.95, p=0.002). The previously developed risk calculator generally underestimated the risks of prostate cancer and high grade prostate cancer. Conclusions Body mass index provided independently predictive information regarding the risks of prostate cancer and high grade prostate cancer after adjusting for other risk factors. Body mass index, especially in men with a known family history of prostate cancer, should be considered for inclusion in any clinical assessment of prostate cancer risk and recommendations regarding prostate biopsy.

AB - Purpose We examine the role of body mass index in the assessment of prostate cancer risk. Materials and Methods A total of 3,258 participants who underwent biopsy (including 1,902 men with a diagnosis of prostate cancer) were identified from the Selenium and Vitamin E Cancer Prevention Trial. The associations of body mass index with prostate cancer and high grade prostate cancer were examined using logistic regression, adjusting for age, race, body mass index adjusted prostate specific antigen, digital rectal examination, family history of prostate cancer, biopsy history, prostate specific antigen velocity, and time between study entry and the last biopsy. The prediction models were compared with our previously developed body mass index adjusted Prostate Cancer Prevention Trial prostate cancer risk calculator. Results Of the study subjects 49.1% were overweight and 29.3% were obese. After adjustment, among men without a known family history of prostate cancer, increased body mass index was not associated with a higher risk of prostate cancer (per one-unit increase in logBMI OR 0.83, p=0.54) but was significantly associated with a higher risk of high grade prostate cancer (ie Gleason score 7 or greater prostate cancer) (OR 2.31, p=0.03). For men with a known family history of prostate cancer the risks of prostate cancer and high grade prostate cancer increased rapidly as body mass index increased (prostate cancer OR 3.73, p=0.02; high grade prostate cancer OR 7.95, p=0.002). The previously developed risk calculator generally underestimated the risks of prostate cancer and high grade prostate cancer. Conclusions Body mass index provided independently predictive information regarding the risks of prostate cancer and high grade prostate cancer after adjusting for other risk factors. Body mass index, especially in men with a known family history of prostate cancer, should be considered for inclusion in any clinical assessment of prostate cancer risk and recommendations regarding prostate biopsy.

KW - body mass index

KW - neoplasm grading

KW - prostate-specific antigen

KW - prostatic neoplasms

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=84921983353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921983353&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2014.04.015

DO - 10.1016/j.juro.2014.04.015

M3 - Article

C2 - 24747090

AN - SCOPUS:84921983353

VL - 192

SP - 1094

EP - 1099

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 4

ER -