Is Rapamycin a Dietary Restriction Mimetic?

Archana Unnikrishnan, Kavitha Kurup, Adam B. Salmon, Arlan Richardson

Research output: Contribution to journalArticle

Abstract

Since the initial suggestion that rapamycin, an inhibitor of target of rapamycin (TOR) nutrient signaling, increased lifespan comparable to dietary restriction, investigators have viewed rapamycin as a potential dietary restriction mimetic. Both dietary restriction and rapamycin increase lifespan across a wide range of evolutionarily diverse species (including yeast, Caenorhabditis elegans, Drosophila, and mice) as well as reducing pathology and improving physiological functions that decline with age in mice. The purpose of this article is to review the research comparing the effect of dietary restriction and rapamycin in mice. The current data show that dietary restriction and rapamycin have different effects on many pathways and molecular processes. In addition, these interventions affect the lifespan of many genetically manipulated mouse models differently. In other words, while dietary restriction and rapamycin may have similar effects on some pathways and processes; overall, they affect many pathways/processes quite differently. Therefore, rapamycin is likely not a true dietary restriction mimetic. Rather dietary restriction and rapamycin appear to be increasing lifespan and retarding aging largely through different mechanisms/pathways, suggesting that a combination of dietary restriction and rapamycin will have a greater effect on lifespan than either manipulation alone.

Original languageEnglish (US)
Pages (from-to)4-13
Number of pages10
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences
Volume75
Issue number1
DOIs
StatePublished - Jan 1 2020

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Sirolimus
Caenorhabditis elegans
Drosophila
Yeasts
Research Personnel
Pathology
Food

Keywords

  • Dietary restriction
  • Insulin sensitivity
  • Lifespan
  • Rapamycin
  • TOR

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Is Rapamycin a Dietary Restriction Mimetic? / Unnikrishnan, Archana; Kurup, Kavitha; Salmon, Adam B.; Richardson, Arlan.

In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 75, No. 1, 01.01.2020, p. 4-13.

Research output: Contribution to journalArticle

Unnikrishnan, Archana ; Kurup, Kavitha ; Salmon, Adam B. ; Richardson, Arlan. / Is Rapamycin a Dietary Restriction Mimetic?. In: The journals of gerontology. Series A, Biological sciences and medical sciences. 2020 ; Vol. 75, No. 1. pp. 4-13.
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