Is race important in genomic classification of hematological neoplasms?

Huijun Huang, Junying Wu, Tiejun Qin, Zefeng Xu, Shiqiang Qu, Lijuan Pan, Wenyu Cai, Jinqin Liu, Huijun Wang, Qi Sun, Meng Jiao, Qingyan Gao, Gang Huang, Robert Peter Gale, Bing Li, Zhijian Xiao

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

In recent years, genome-based classifications for hematological neoplasms have been proposed successively and proved to be more accurate than histologic classifications. However, some previous studies have reported the racial differences of genetic landscape in persons with hematological neoplasms including myelodysplastic syndromes (MDS), which may cause a genomic classification based on a particular ethnic group does not operate in other races. To determine whether race plays an important role in the genomic-based classification, we validated a newly proposed genomic classification of MDS (J Clin Oncol.2021; JCO2001659), which was based on a large European database, in Chinese patients from our center. Our results showed significant differences between Chinese and European patients including proportion of each group to overall cohort when applying this novel genomic classification. Our data indicate that a genomic classification of hematological neoplasms probably should be revised according to specific genetic features in different races.

Original languageEnglish (US)
Pages (from-to)728-732
Number of pages5
JournalHematological Oncology
Volume39
Issue number5
DOIs
StatePublished - Dec 2021
Externally publishedYes

Keywords

  • genetic topographies
  • genomic classification
  • hematological neoplasms
  • myelodysplastic syndromes
  • racial differences

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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