Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data

Brenna L. Hughes, Rebecca G. Clifton, John C. Hauth, Kenneth J. Leveno, Leslie Myatt, Uma M. Reddy, Michael W. Varner, Ronald J. Wapner, Brian M. Mercer, Alan M. Peaceman, Susan M. Ramin, Jorge E. Tolosa, George Saade, Yoram Sorokin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective The objective of this study was to examine whether there is an association between insulin resistance and subsequent development of puerperal infection by measuring insulin resistance in the mid-trimester using the homeostasis model assessment (HOMA:IR). Methods Secondary analysis of low-risk nulliparas enrolled in a multicenter preeclampsia prevention trial. HOMA:IR was measured on fasting plasma glucose and insulin concentrations among low-risk nulliparas between 22 and 26 weeks' gestation. Median HOMA:IR was compared between women who did and did not develop puerperal infection using Wilcoxon rank sum test. Logistic regression was used to control for potential confounders. Results Of 1,180 women with fasting glucose and insulin available, 121 (10.3%) had a puerperal infection. Median HOMA:IR was higher among those with subsequent puerperal infection (4.3 [interquartile, IQR: 2.2–20.5] vs. 2.6 [IQR: 1.5–6.7], p <0.0001). After controlling for potentially confounding variables HOMA:IR was only marginally associated with an increased risk of development of puerperal infection, adjusted odds ratio: 1.01 (95% confidence interval: 1.00–1.02; p = 0.04) per unit increase. Elevated HOMA:IR performed poorly as a predictor of puerperal infection, with a positive predictive value of 15% and a negative predictive value of 92%. Conclusion Though associated with an increased risk of puerperal infection, insulin resistance, measured by HOMA:IR, is not a clinically useful predictor of puerperal infection.

Original languageEnglish (US)
JournalAmerican Journal of Perinatology
DOIs
StateAccepted/In press - Mar 14 2016
Externally publishedYes

Fingerprint

Puerperal Infection
Insulin Resistance
Nonparametric Statistics
Fasting
Insulin
Glucose
Confounding Factors (Epidemiology)
Pre-Eclampsia
Homeostasis
Logistic Models
Odds Ratio
Confidence Intervals
Pregnancy

Keywords

  • insulin resistance
  • predictor
  • pregnancy
  • puerperal infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data. / Hughes, Brenna L.; Clifton, Rebecca G.; Hauth, John C.; Leveno, Kenneth J.; Myatt, Leslie; Reddy, Uma M.; Varner, Michael W.; Wapner, Ronald J.; Mercer, Brian M.; Peaceman, Alan M.; Ramin, Susan M.; Tolosa, Jorge E.; Saade, George; Sorokin, Yoram.

In: American Journal of Perinatology, 14.03.2016.

Research output: Contribution to journalArticle

Hughes, BL, Clifton, RG, Hauth, JC, Leveno, KJ, Myatt, L, Reddy, UM, Varner, MW, Wapner, RJ, Mercer, BM, Peaceman, AM, Ramin, SM, Tolosa, JE, Saade, G & Sorokin, Y 2016, 'Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data', American Journal of Perinatology. https://doi.org/10.1055/s-0036-1583188
Hughes, Brenna L. ; Clifton, Rebecca G. ; Hauth, John C. ; Leveno, Kenneth J. ; Myatt, Leslie ; Reddy, Uma M. ; Varner, Michael W. ; Wapner, Ronald J. ; Mercer, Brian M. ; Peaceman, Alan M. ; Ramin, Susan M. ; Tolosa, Jorge E. ; Saade, George ; Sorokin, Yoram. / Is Mid-trimester Insulin Resistance Predictive of Subsequent Puerperal Infection? A Secondary Analysis of Randomized Trial Data. In: American Journal of Perinatology. 2016.
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abstract = "Objective The objective of this study was to examine whether there is an association between insulin resistance and subsequent development of puerperal infection by measuring insulin resistance in the mid-trimester using the homeostasis model assessment (HOMA:IR). Methods Secondary analysis of low-risk nulliparas enrolled in a multicenter preeclampsia prevention trial. HOMA:IR was measured on fasting plasma glucose and insulin concentrations among low-risk nulliparas between 22 and 26 weeks' gestation. Median HOMA:IR was compared between women who did and did not develop puerperal infection using Wilcoxon rank sum test. Logistic regression was used to control for potential confounders. Results Of 1,180 women with fasting glucose and insulin available, 121 (10.3{\%}) had a puerperal infection. Median HOMA:IR was higher among those with subsequent puerperal infection (4.3 [interquartile, IQR: 2.2–20.5] vs. 2.6 [IQR: 1.5–6.7], p <0.0001). After controlling for potentially confounding variables HOMA:IR was only marginally associated with an increased risk of development of puerperal infection, adjusted odds ratio: 1.01 (95{\%} confidence interval: 1.00–1.02; p = 0.04) per unit increase. Elevated HOMA:IR performed poorly as a predictor of puerperal infection, with a positive predictive value of 15{\%} and a negative predictive value of 92{\%}. Conclusion Though associated with an increased risk of puerperal infection, insulin resistance, measured by HOMA:IR, is not a clinically useful predictor of puerperal infection.",
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AU - Hughes, Brenna L.

AU - Clifton, Rebecca G.

AU - Hauth, John C.

AU - Leveno, Kenneth J.

AU - Myatt, Leslie

AU - Reddy, Uma M.

AU - Varner, Michael W.

AU - Wapner, Ronald J.

AU - Mercer, Brian M.

AU - Peaceman, Alan M.

AU - Ramin, Susan M.

AU - Tolosa, Jorge E.

AU - Saade, George

AU - Sorokin, Yoram

PY - 2016/3/14

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N2 - Objective The objective of this study was to examine whether there is an association between insulin resistance and subsequent development of puerperal infection by measuring insulin resistance in the mid-trimester using the homeostasis model assessment (HOMA:IR). Methods Secondary analysis of low-risk nulliparas enrolled in a multicenter preeclampsia prevention trial. HOMA:IR was measured on fasting plasma glucose and insulin concentrations among low-risk nulliparas between 22 and 26 weeks' gestation. Median HOMA:IR was compared between women who did and did not develop puerperal infection using Wilcoxon rank sum test. Logistic regression was used to control for potential confounders. Results Of 1,180 women with fasting glucose and insulin available, 121 (10.3%) had a puerperal infection. Median HOMA:IR was higher among those with subsequent puerperal infection (4.3 [interquartile, IQR: 2.2–20.5] vs. 2.6 [IQR: 1.5–6.7], p <0.0001). After controlling for potentially confounding variables HOMA:IR was only marginally associated with an increased risk of development of puerperal infection, adjusted odds ratio: 1.01 (95% confidence interval: 1.00–1.02; p = 0.04) per unit increase. Elevated HOMA:IR performed poorly as a predictor of puerperal infection, with a positive predictive value of 15% and a negative predictive value of 92%. Conclusion Though associated with an increased risk of puerperal infection, insulin resistance, measured by HOMA:IR, is not a clinically useful predictor of puerperal infection.

AB - Objective The objective of this study was to examine whether there is an association between insulin resistance and subsequent development of puerperal infection by measuring insulin resistance in the mid-trimester using the homeostasis model assessment (HOMA:IR). Methods Secondary analysis of low-risk nulliparas enrolled in a multicenter preeclampsia prevention trial. HOMA:IR was measured on fasting plasma glucose and insulin concentrations among low-risk nulliparas between 22 and 26 weeks' gestation. Median HOMA:IR was compared between women who did and did not develop puerperal infection using Wilcoxon rank sum test. Logistic regression was used to control for potential confounders. Results Of 1,180 women with fasting glucose and insulin available, 121 (10.3%) had a puerperal infection. Median HOMA:IR was higher among those with subsequent puerperal infection (4.3 [interquartile, IQR: 2.2–20.5] vs. 2.6 [IQR: 1.5–6.7], p <0.0001). After controlling for potentially confounding variables HOMA:IR was only marginally associated with an increased risk of development of puerperal infection, adjusted odds ratio: 1.01 (95% confidence interval: 1.00–1.02; p = 0.04) per unit increase. Elevated HOMA:IR performed poorly as a predictor of puerperal infection, with a positive predictive value of 15% and a negative predictive value of 92%. Conclusion Though associated with an increased risk of puerperal infection, insulin resistance, measured by HOMA:IR, is not a clinically useful predictor of puerperal infection.

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KW - predictor

KW - pregnancy

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