Abstract
Microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. A number of studies have indicated that insulin resistance, increased blood pressure and dyslipidaemia precede the onset of clinical diabetes. We examined various correlates of microalbuminuria in 1,298 non-diabetic subjects who participated in the Mexico city Diabetes Study, a population-based study of diabetes and cardiovascular risk factors. Both parental history of diabetes and impaired glucose tolerance were significantly associated with microalbuminuria. These results were not explained by differences in age or blood pressure between subjects with or without a parental history of diabetes or impaired glucose tolerance. In addition, subjects with microalbuminuria had increased 2-h insulin and triglyceride concentrations, a higher prevalence of hypertension, and decreased high density lipoprotein cholesterol concentrations relative to subjects without microalbuminuria. These results suggest that microalbuminuria may be a feature of the prediabetic state.
Original language | English (US) |
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Pages (from-to) | 1002-1006 |
Number of pages | 5 |
Journal | Diabetologia: Clinical and Experimental Diabetes and Metabolism |
Volume | 36 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1993 |
Keywords
- Microalbuminuria
- Type 2 (non-insulin-dependent) diabetes mellitus
- blood pressure
- dyslipidaemia
- insulin resistance
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism