Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study

S. M. Haffner, C. Gonzales, R. A. Valdez, L. Mykkänen, H. P. Hazuda, B. D. Mitchell, A. Monterrosa, M. P. Stern

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Microalbuminuria is associated with increased cardiovascular mortality in both diabetic and non-diabetic subjects. A number of studies have indicated that insulin resistance, increased blood pressure and dyslipidaemia precede the onset of clinical diabetes. We examined various correlates of microalbuminuria in 1,298 non-diabetic subjects who participated in the Mexico city Diabetes Study, a population-based study of diabetes and cardiovascular risk factors. Both parental history of diabetes and impaired glucose tolerance were significantly associated with microalbuminuria. These results were not explained by differences in age or blood pressure between subjects with or without a parental history of diabetes or impaired glucose tolerance. In addition, subjects with microalbuminuria had increased 2-h insulin and triglyceride concentrations, a higher prevalence of hypertension, and decreased high density lipoprotein cholesterol concentrations relative to subjects without microalbuminuria. These results suggest that microalbuminuria may be a feature of the prediabetic state.

Original languageEnglish (US)
Pages (from-to)1002-1006
Number of pages5
JournalDiabetologia: Clinical and Experimental Diabetes and Metabolism
Volume36
Issue number10
DOIs
StatePublished - Oct 1993

Keywords

  • Microalbuminuria
  • Type 2 (non-insulin-dependent) diabetes mellitus
  • blood pressure
  • dyslipidaemia
  • insulin resistance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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