Iron mediates trichomonas vaginalis resistance to complement lysis

John F. Alderete, Daniele Provenzano, Michael W. Lehker

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Trichomonas vaginalis, a sexually transmitted disease agent in humans, is readily lysed by activation of the alternative complement pathway. The parasite became resistant following growth in medium supplemented by iron compared to parasites grown in medium depleted of iron, which were readily killed by complement. The resistance to complement was dependent on iron concentration while divalent cations other than iron were ineffective, showing specific regulation of this property by iron. Lactoferrin, but not transferrin, rendered low-iron-parasites resistant to complement lysis, reinforcing thein vivomodulation by a known source of iron for this parasite. Pretreatment of high-iron, complement-resistant parasites with proteinase inhibitors resulted in lysis by complement, indicating that resistance was likely due to proteinase degradation of C3 on the trichomonal surface.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalMicrobial Pathogenesis
Volume19
Issue number2
DOIs
StatePublished - Aug 1995

Keywords

  • Complement
  • Host-parasite
  • Trichomonas vaginalis
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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