TY - JOUR
T1 - Ipsilateral synkinesia involves the supplementary motor area
AU - Salardini, Arash
AU - Narayanan, Nandakumar S.
AU - Arora, Jagriti
AU - Constable, Todd
AU - Jabbari, Bahman
PY - 2012/8/15
Y1 - 2012/8/15
N2 - The supplementary motor area coordinates movements. Synkinesia is a rare disorder in which an involuntary movement occurs coordinated with a voluntary movement. Here, we test the hypothesis that the supplementary motor area is involved in involuntary coordination of movement. We collected functional magnetic resonance imaging (fMRI) data from two patients with ipsilateral hand-foot synkinesia and two control participants while they performed rhythmic tasks. In synkinesia patients, both the supplementary motor area and the foot motor cortex were significantly activated during the hand motor task. This pattern was not seen in controls. Our findings suggest that the supplementary motor area plays a central role in involuntary coordination observed in synkinesia, and provides insight into how the supplementary motor area orchestrates movements.
AB - The supplementary motor area coordinates movements. Synkinesia is a rare disorder in which an involuntary movement occurs coordinated with a voluntary movement. Here, we test the hypothesis that the supplementary motor area is involved in involuntary coordination of movement. We collected functional magnetic resonance imaging (fMRI) data from two patients with ipsilateral hand-foot synkinesia and two control participants while they performed rhythmic tasks. In synkinesia patients, both the supplementary motor area and the foot motor cortex were significantly activated during the hand motor task. This pattern was not seen in controls. Our findings suggest that the supplementary motor area plays a central role in involuntary coordination observed in synkinesia, and provides insight into how the supplementary motor area orchestrates movements.
KW - FMRI
KW - Hand-foot coordination
KW - Ipsilateral synkinesia
KW - Motor cortex
KW - Supplementary motor area
UR - http://www.scopus.com/inward/record.url?scp=84864292772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864292772&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2012.06.060
DO - 10.1016/j.neulet.2012.06.060
M3 - Article
C2 - 22759337
AN - SCOPUS:84864292772
SN - 0304-3940
VL - 523
SP - 135
EP - 138
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -