Abstract
Thirty-one human subjects were administered a neuroendocrine challenge with the 5-HT(la) agonist ipsapirone after completing six sessions of a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (c) (PSAP), in order to determine if a laboratory measure of aggression was related to serotonin function. Subjects who showed more aggressive responding on the PSAP (n = 11) had a significantly blunted temperature response to ipsapirone compared to those with less aggressive responding (n = 20). There was no difference between the two groups on the cortisol response to ipsapirone. This study supports a relationship between serotonin function and aggression as measured in the human laboratory, similar to the well- documented association between self-reported aggression and serotonin.
Original language | English (US) |
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Pages (from-to) | 31-38 |
Number of pages | 8 |
Journal | Psychiatry Research |
Volume | 81 |
Issue number | 1 |
DOIs | |
State | Published - Oct 19 1998 |
Externally published | Yes |
Keywords
- Cortisol
- Serotonin
- Substance abuse
- Temperature
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry