Ipsapirone neuroendocrine challenge: Relationship to aggression as measured in the human laboratory

F. Gerard Moeller; Terry Allen; Don R. Cherek; Donald M. Dougherty; Scott Lane; Alan C. Swann

doi:10.1016/S0165-1781(98)00081-X

Ipsapirone neuroendocrine challenge: Relationship to aggression as measured in the human laboratory

F. Gerard Moeller, Terry Allen, Don R. Cherek, Donald M. Dougherty, Scott Lane, Alan C. Swann

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Thirty-one human subjects were administered a neuroendocrine challenge with the 5-HT(la) agonist ipsapirone after completing six sessions of a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (c) (PSAP), in order to determine if a laboratory measure of aggression was related to serotonin function. Subjects who showed more aggressive responding on the PSAP (n = 11) had a significantly blunted temperature response to ipsapirone compared to those with less aggressive responding (n = 20). There was no difference between the two groups on the cortisol response to ipsapirone. This study supports a relationship between serotonin function and aggression as measured in the human laboratory, similar to the well- documented association between self-reported aggression and serotonin.

Original language	English (US)
Pages (from-to)	31-38
Number of pages	8
Journal	Psychiatry Research
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(98)00081-X
State	Published - Oct 19 1998
Externally published	Yes

Keywords

Cortisol
Serotonin
Substance abuse
Temperature

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/S0165-1781(98)00081-X

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