Involvement of the complement system in antibody-mediated post-exposure protection against human immunodeficiency virus type 1

Marie Claire Gauduin, Raymond Weir, Michael S.C. Fung, Richard A. Koup

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    We previously reported that passive transfer of a murine V3-specific monoclonal antibody (BAT123) to hu-PBL-SCID mice challenged with HIV-1(LAI) confers postexposure protection from infection. The role of the Fc fragment of this antibody as well as the involvement of the complement system in protection were evaluated in vivo. When we compared the postexposure protection offered by BAT123 and CGP 47 439, a chimeric form of BAT123 in which the murine Fc domain has been replaced by a human IgG1 Fc domain, CGP 47 439 failed to provide postexposure protection against HIV-1(LAI) despite having similar pharmacokinetics and in vitro neutralizing activity. Furthermore, when hu-PBL-SCID mice were treated with cobra venom factor, which inactivates serum complement activity, the postexposure protective ability of BAT123 was abrogated. These findings suggest that the complement system is involved in the passive protection against HIV-1 infection conferred by the murine monoclonal antibody BAT123 in hu-PBL-SCID mice.

    Original languageEnglish (US)
    Pages (from-to)205-211
    Number of pages7
    JournalAIDS Research and Human Retroviruses
    Volume14
    Issue number3
    DOIs
    StatePublished - Feb 10 1998

    ASJC Scopus subject areas

    • Immunology
    • Virology
    • Infectious Diseases

    Fingerprint Dive into the research topics of 'Involvement of the complement system in antibody-mediated post-exposure protection against human immunodeficiency virus type 1'. Together they form a unique fingerprint.

    Cite this