Involvement of the cholinergic system in the precocious puberty caused by estradiol in immature female rats

A. T. Modak, W. B. Stavinoha, N. Hagino

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Subcutaneous administration of 0.05 μg estradiol benzoate to sexually immature female rats caused precocious ovulation and a decreased acetylcholine content in the hypothalamus and the amygdala. A higher dose of estradiol benzoate, 2 μg/rat, did not stimulate ovulation but did cause a further decrease in the acetylcholine content in the hypothalamus and the amygdala. The steady state levels of acetylcholine in the hippocampus and the striatum were unchanged with either dose of estradiol. These observations suggest a relationship between the occurrence of ovulation and the decrease in the steady state level of acetylcholine in the hypothalamus and amygdala in sexually immature rats after estradiol treatment.

Original languageEnglish (US)
Pages (from-to)344-350
Number of pages7
JournalArchives internationales de pharmacodynamie et de therapie
Volume241
Issue number2
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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