Investigations on insulin kinetics

J. Radziuk, S. Pye, T. Morishima, G. Davies, D. E. Seigler, M. L. Reeves

Research output: Contribution to journalConference articlepeer-review


Insulin is secreted into the portal vein by the pancreas at varying rates. The insulin secretion rate is calculated by deconvolution from C-peptide concentrations, a peptide that is co-secreted with insulin on an equimolar basis. This calculation has been experimentally validated. It is concluded that, in dogs, as portal insulin levels increase to 600uU/ml, the hepatic extraction of insulin falls by approximately 50% and the fractional disappearance rate of insulin by two thirds. This suggests that insulin removal by the liver is the principal component of the metabolic clearance of insulin and that it may vary under physiological circumstances. This paper provides approaches, both experimental and quantitative for determining the major parameters involved in insulin kinetics - its rate of secretion and removal by the liver, when these are varying.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalIFAC Proceedings Series
Issue number1
StatePublished - Dec 1 1989
Externally publishedYes
EventIFAC Symposium on Modelling and Control in Biomedical Systems - Venice, Italy
Duration: Apr 6 1988Apr 8 1988

ASJC Scopus subject areas

  • Engineering(all)


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