Investigation of tcdd half-life heterogeneity in veterans of operation ranch hand

Joel E. Michalek, Ram C. Tripathi, Samuel P. Caudill, James L. Pirkle

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The half-life of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the contaminant of Agent Orange, has been recently estimated in 36 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam, as 7.1 yr with a 90% confidence interval of 5.8-9.6 yr. We investigated the variability of TCDD half-life with percent body fat in these 36 Ranch Hand veterans who have two TCDD assay results from serum drawn in 1982 and 1987. Using a repeated measures linear model, we found a marginally significant change in half-life with percentage of body fat fp -.09) and no statistically significant change in half-life with relative changes in percentage of body fat from 1982 to 1987 (p -.60).

Original languageEnglish (US)
Pages (from-to)29-38
Number of pages10
JournalJournal of Toxicology and Environmental Health
Volume35
Issue number1
DOIs
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Toxicology
  • Pollution

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