Abstract
Hemoglobin-styrene oxide adducts in blood was studied as a molecular biomarker of worker exposed to styrene. Determination of protein-styrene oxide adducts in different biological samples with modified Ra-Ni procedure was described in this paper. The following biological samples were investigated:flash rat blood reacted with styrene oxide in vitro (rat blood reacted with styrene or styrene oxide in vivos vein blood from workers in two factories who exposed to styrene. The data showed that there was a good dose-response relationship between reacting dose of styrene oxide or styrene and amount of protein-styrene oxide adducts in both in vitro and in vivo experiments.For human samples,a dose-response relationship between adducts and exposure was found in glass fiber factory,but none in piano manufacture plant.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6-11 |
| Number of pages | 6 |
| Journal | Huanjing Kexue/Environmental Science |
| Volume | 21 |
| Issue number | 5 |
| State | Published - 2000 |
| Externally published | Yes |
Keywords
- Molecular biomarker
- Protein adduct
- Styrene oxide
ASJC Scopus subject areas
- General Environmental Science