Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets

William T Phillips, R. Klipper, A. S. Rudolph, B. Goins

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A transient thrombocytopenia has been reported in rats after infusion of liposome encapsulated hemoglobin (LEH). Specific quantitation of the thrombocytopenia is difficult due to the inference of LEH with platelet counting by light scattering methods due to an overlap in their size. In order to study the effect of LEH on platelets biodistribution, platelets were labeled with indium-111 and monitored with a gamma scintigraphic camera. Indium-111 labelled platelets can be used to study mechanisms of LEH-induced thrombocytopenia and aid in the development of LEH formulations not associated with thrombocytopenia.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994

Fingerprint

Indium
Liposomes
Hemoglobin
Platelets
Hemoglobins
Blood Platelets
Thrombocytopenia
Gamma Cameras
Light scattering
Rats
Cameras
Light

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets. / Phillips, William T; Klipper, R.; Rudolph, A. S.; Goins, B.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 5, 11.1994.

Research output: Contribution to journalArticle

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