Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets

W. T. Phillips; R. Klipper; A. S. Rudolph; B. Goins

Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets

W. T. Phillips, R. Klipper, A. S. Rudolph, B. Goins

Department of Radiology

Research output: Contribution to journal › Conference article › peer-review

Abstract

A transient thrombocytopenia has been reported in rats after infusion of liposome encapsulated hemoglobin (LEH). Specific quantitation of the thrombocytopenia is difficult due to the inference of LEH with platelet counting by light scattering methods due to an overlap in their size. In order to study the effect of LEH on platelets biodistribution, platelets were labeled with indium-111 and monitored with a gamma scintigraphic camera. Indium-111 labelled platelets can be used to study mechanisms of LEH-induced thrombocytopenia and aid in the development of LEH formulations not associated with thrombocytopenia.

Original language	English (US)
Pages (from-to)	A144
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	22
Issue number	5
State	Published - Nov 1 1994
Event	Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA Duration: Jul 24 1994 → Jul 27 1994

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

Cite this

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title = "Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets",

abstract = "A transient thrombocytopenia has been reported in rats after infusion of liposome encapsulated hemoglobin (LEH). Specific quantitation of the thrombocytopenia is difficult due to the inference of LEH with platelet counting by light scattering methods due to an overlap in their size. In order to study the effect of LEH on platelets biodistribution, platelets were labeled with indium-111 and monitored with a gamma scintigraphic camera. Indium-111 labelled platelets can be used to study mechanisms of LEH-induced thrombocytopenia and aid in the development of LEH formulations not associated with thrombocytopenia.",

author = "Phillips, {W. T.} and R. Klipper and Rudolph, {A. S.} and B. Goins",

year = "1994",

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pages = "A144",

journal = "Biomaterials, Artificial Cells, and Immobilization Biotechnology",

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note = "Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) ; Conference date: 24-07-1994 Through 27-07-1994",

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T1 - Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets

AU - Phillips, W. T.

AU - Klipper, R.

AU - Rudolph, A. S.

AU - Goins, B.

PY - 1994/11/1

Y1 - 1994/11/1

N2 - A transient thrombocytopenia has been reported in rats after infusion of liposome encapsulated hemoglobin (LEH). Specific quantitation of the thrombocytopenia is difficult due to the inference of LEH with platelet counting by light scattering methods due to an overlap in their size. In order to study the effect of LEH on platelets biodistribution, platelets were labeled with indium-111 and monitored with a gamma scintigraphic camera. Indium-111 labelled platelets can be used to study mechanisms of LEH-induced thrombocytopenia and aid in the development of LEH formulations not associated with thrombocytopenia.

AB - A transient thrombocytopenia has been reported in rats after infusion of liposome encapsulated hemoglobin (LEH). Specific quantitation of the thrombocytopenia is difficult due to the inference of LEH with platelet counting by light scattering methods due to an overlap in their size. In order to study the effect of LEH on platelets biodistribution, platelets were labeled with indium-111 and monitored with a gamma scintigraphic camera. Indium-111 labelled platelets can be used to study mechanisms of LEH-induced thrombocytopenia and aid in the development of LEH formulations not associated with thrombocytopenia.

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UR - http://www.scopus.com/inward/citedby.url?scp=17444440182&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:17444440182

SN - 2169-1401

VL - 22

SP - A144

JO - Biomaterials, Artificial Cells, and Immobilization Biotechnology

JF - Biomaterials, Artificial Cells, and Immobilization Biotechnology

IS - 5

T2 - Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI)

Y2 - 24 July 1994 through 27 July 1994

ER -

Investigation of liposome encapsulated hemoglobin/platelet interactions using indium-111 labeled platelets

Abstract

ASJC Scopus subject areas

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