Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer

Robert A. Smith, Joanne E. Curran, Stephen R. Weinstein, Lyn R. Griffiths

    Research output: Contribution to journalArticle

    10 Scopus citations

    Abstract

    Background: Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 (GSTZ1) gene are associated with the development of sporadic breast cancer. Methods: DNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chisquare and CLUMP analysis. Results: Chi-squared analysis gave a X2 value of 4.77 (three degrees of freedom) with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies. Conclusion: Statistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.

    Original languageEnglish (US)
    Pages (from-to)409-411
    Number of pages3
    JournalBreast Cancer Research
    Volume3
    Issue number6
    DOIs
    StatePublished - Dec 1 2001

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    Keywords

    • GSTZ1
    • Glutathione S-transferase zeta
    • Sporadic breast cancer

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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