Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer

Robert A. Smith, Joanne E. Curran, Stephen R. Weinstein, Lyn R. Griffiths

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 (GSTZ1) gene are associated with the development of sporadic breast cancer. Methods: DNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chisquare and CLUMP analysis. Results: Chi-squared analysis gave a X2 value of 4.77 (three degrees of freedom) with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies. Conclusion: Statistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.

Original languageEnglish (US)
Pages (from-to)409-411
Number of pages3
JournalBreast Cancer Research
Volume3
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

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Glutathione Transferase
Breast Neoplasms
Genes
Alleles
Gene Frequency
Population
Digestion
Genotype
Polymerase Chain Reaction
DNA
Enzymes
Neoplasms

Keywords

  • Glutathione S-transferase zeta
  • GSTZ1
  • Sporadic breast cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer. / Smith, Robert A.; Curran, Joanne E.; Weinstein, Stephen R.; Griffiths, Lyn R.

In: Breast Cancer Research, Vol. 3, No. 6, 2001, p. 409-411.

Research output: Contribution to journalArticle

Smith, Robert A. ; Curran, Joanne E. ; Weinstein, Stephen R. ; Griffiths, Lyn R. / Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer. In: Breast Cancer Research. 2001 ; Vol. 3, No. 6. pp. 409-411.
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