Investigation of a new arthrographic contrast agent: Iotrol

Jose Guerra, Donald Resnick, Parviz Haghighi, Milos Sovak, Robert Cone

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A new nonionic dimer (Iotrol; Schering AG) and diatrizoate meglumine-diatrizoate sodium (Renografin®-60; Squibb) were compared as arthrographic agents by injecting these substances into the knees of rabbits. Three experienced arthrographers judged the image quality produced by Iotrol to be superior to that of Renografin-60. Following animal sacrifice, histologic examination of the synovium revealed a significant difference in the inflammatory response evoked by the contrast agents: Iotrol caused less inflammation. In a second group of rabbits, methylprednisolone was subcutaneously injected 24 hours before the arthrographic studies. The methylprednisolone significantly reduced the inflammation in the Renografin-60 subgroup when compared with the nonmedicated counterparts. No significant effect was noted in a like comparison with Iotrol. In addition, the administration of methylprednisolone led to a deterioration of the radiographic images. Based upon our data, we believe Iotrol is superior to Renografin-60 as an arthrographic agent.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalInvestigative Radiology
Issue number3
StatePublished - 1984


  • Arthrography
  • Contrast media
  • Iotrol
  • Nonionic dimer
  • Synovial inflammation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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