Investigating mechanisms of chronic kidney disease in mouse models

Allison A. Eddy, Jesús M. López-Guisa, Daryl M. Okamura, Ikuyo Yamaguchi

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

Animal models of chronic kidney disease (CKD) are important experimental tools that are used to investigate novel mechanistic pathways and to validate potential new therapeutic interventions prior to pre-clinical testing in humans. Over the past several years, mouse CKD models have been extensively used for these purposes. Despite significant limitations, the model of unilateral ureteral obstruction (UUO) has essentially become the high-throughput in vivo model, as it recapitulates the fundamental pathogenetic mechanisms that typify all forms of CKD in a relatively short time span. In addition, several alternative mouse models are available that can be used to validate new mechanistic paradigms and/or novel therapies. Here, we review several models- both genetic and experimentally induced-that provide investigators with an opportunity to include renal functional study end-points together with quantitative measures of fibrosis severity, something that is not possible with the UUO model.

Original languageEnglish (US)
Pages (from-to)1233-1247
Number of pages15
JournalPediatric Nephrology
Volume27
Issue number8
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Animal models
  • Chronic kidney disease
  • Collagen
  • Extracellular matrix
  • Fibrosis
  • Unilateral ureteral obstruction

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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